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Expression Levels of microRNA Processing Enzymes Dicer and Drosha in Epithelial Skin Cancer

NCT ID: NCT00849914

Last Updated: 2012-10-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

28 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-07-31

Study Completion Date

2009-02-28

Brief Summary

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MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the expression profiles for the two most important miRNA processing enzymes Dicer and Drosha of actinic keratoses, basal cell carcinoma and squamous cell carcinoma are compared to healthy skin tissue.

Detailed Description

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Conditions

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Skin Cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Patients with actinic keratoses of the skin

No interventions assigned to this group

2

Patients with basal cell carcinoma of the skin

No interventions assigned to this group

3

Patients with squamous cell carcinoma of the skin

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients with actinic keratoses, squamous cell carcinoma or basal cell carcinoma of the skin

Exclusion Criteria

* Patients under 18 years of age
* Patients with other forms of cancer in previous medical history
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ruhr University of Bochum

OTHER

Sponsor Role lead

Responsible Party

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Michael Sand

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Prof. Dr. Peter Altmeyer

Role: PRINCIPAL_INVESTIGATOR

Department of Dermatology and Allergology, Ruhr-University Bochum

Locations

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Department of Dermatology and Allergology, Ruhr-University Bochum

Bochum, , Germany

Site Status

Countries

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Germany

References

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Sand M, Gambichler T, Skrygan M, Sand D, Scola N, Altmeyer P, Bechara FG. Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer. Cancer Invest. 2010 Jul;28(6):649-53. doi: 10.3109/07357901003630918.

Reference Type RESULT
PMID: 20210522 (View on PubMed)

Other Identifiers

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005

Identifier Type: -

Identifier Source: org_study_id