A Training Set for the HRD Model in EOC

NCT ID: NCT04651933

Last Updated: 2020-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-11-26

Study Completion Date

2022-11-26

Brief Summary

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A homologous recombination deficiency (HRD) scoring model based on loss of heterozygosity (LOH) is little explored in epithelial ovarian cancer (EOC) patients. This study would recruit 200 Chinese EOC patients with known BRCA1/2 mutation status and resistance to platinum-based chemotherapy. A LOH-HRD model is to be constructed based on the genetic testing in these patients. The mutated genes, HRD score model and their relationship with the prognosis, would provide a full description of for the Chinese EOC patients, and a potential explanation of platinum-resistance in such population.

Detailed Description

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Conditions

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Epithelial Ovarian Cancer BRCA Mutation Loss of Heterozygosity Prognosis Platinum Resistance Homologous Recombination Deficiency

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Epithelial ovarian cancer patients sensitive to platinum based chemotherapy

Homologous recombination deficiency model

Intervention Type GENETIC

A homologous recombination deficiency (HRD) scoring model based on loss of heterozygosity (LOH)

Epithelial ovarian cancer patients resistant to platinum based chemotherapy

Homologous recombination deficiency model

Intervention Type GENETIC

A homologous recombination deficiency (HRD) scoring model based on loss of heterozygosity (LOH)

Interventions

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Homologous recombination deficiency model

A homologous recombination deficiency (HRD) scoring model based on loss of heterozygosity (LOH)

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Aged 18 years or older
* Pathological confirmation of epithelial ovarian cancer
* With available tumor tissues
* Given consents to participate the study
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Lei Li

OTHER

Sponsor Role lead

Responsible Party

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Lei Li

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Lei Li, M.D.

Role: PRINCIPAL_INVESTIGATOR

Peking Union Medical College Hospital

Locations

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Lei Li

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Lei Li, M.D.

Role: CONTACT

Phone: +8613911988831

Email: [email protected]

Ming Wu, M.D.

Role: CONTACT

Phone: +8613810224549

Email: [email protected]

Facility Contacts

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Lei Li, MD

Role: primary

Other Identifiers

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EOC-LOH

Identifier Type: -

Identifier Source: org_study_id