Role of microRNA in the Development of Cutaneous Squamous Cell Carcinoma

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-06-30

Study Completion Date

2011-04-30

Brief Summary

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The aim of this study is to analyze the differential expression of the miR transcriptome in the distinctive stages of the development of cutaneous squamous cell carcinoma (C-SCC). In this aim the investigators plan to recruit a cohort of 20 patients suffering of C-SCC and to collect from each of them, biopsies corresponding to i) non UV-exposed areas ii) UV-exposed areas, iii) actinic keratosis and iv) tumoral regions. Total RNAs will be prepared from each biopsy and the miRNA profiles will be characterized using a dedicated miR array.

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Detailed Description

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Conditions

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Cancer of the Skin

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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ARM A

4 distinct biopsies will be taken

1. in a non UV-exposed area (inner arm)
2. in a UV-exposed area (external surface of the forearm)
3. in a pretumoral region (actinic keratosis)
4. inside the tumor

Group Type OTHER

Arm A

Intervention Type GENETIC

4 distinct biopsies will be taken

1. in a non UV-exposed area (inner arm)
2. in a UV-exposed area (external surface of the forearm)
3. in a pretumoral region (actinic keratosis)
4. inside the tumor

Interventions

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Arm A

4 distinct biopsies will be taken

1. in a non UV-exposed area (inner arm)
2. in a UV-exposed area (external surface of the forearm)
3. in a pretumoral region (actinic keratosis)
4. inside the tumor

Intervention Type GENETIC