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Expression Levels of RISC and Microprocessor Complex Components in Epithelial Skin Cancer

NCT ID: NCT01345760

Last Updated: 2012-10-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

44 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-07-31

Study Completion Date

2011-02-28

Brief Summary

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MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study, the investigators examines the expression profiles of the microprocessor complex subunit DGCR8 and the RISC components TARBP1, TARBP2, argonaute-1, argonaute-2 and PACT in epithelial skin cancer and its premalignant stage.

Detailed Description

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Patients with premalignant actinic keratoses, basal cell carcinomas and squamous cell carcinomas were included in the study. Punch biopsies were harvested from the center of the tumors, from sites of healthy skin and a healthy control group. DGCR8, TARBP1, TARBP2, argonaute-1, argonaute-2 and PACT mRNA expression levels were detected by quantitative real-time reverse transcriptase polymerase chain reaction.

Conditions

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Skin Cancer

Keywords

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Basal Cell Carcinoma Squamous Cell Carcinoma Actinic Keratosis microRNA Dicer Drosha RISC microprocessor complex Argonaute DGCR8 TARBP

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Basal Cell Carcinoma

No interventions assigned to this group

Squamous Cell Carcinoma

No interventions assigned to this group

Actinic Keratosis

No interventions assigned to this group

healthy non-lesional skin

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* epithelial skin cancer

Exclusion Criteria

* other known previous malignancies
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ruhr University of Bochum

OTHER

Sponsor Role lead

Responsible Party

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Michael Sand

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Falk G Bechara, PD Dr.

Role: STUDY_DIRECTOR

Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum

Locations

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Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum

Bochum, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

References

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Sand M, Skrygan M, Georgas D, Arenz C, Gambichler T, Sand D, Altmeyer P, Bechara FG. Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer. Mol Carcinog. 2012 Nov;51(11):916-22. doi: 10.1002/mc.20861. Epub 2011 Oct 24.

Reference Type RESULT
PMID: 22025453 (View on PubMed)

Other Identifiers

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1-Sand

Identifier Type: -

Identifier Source: org_study_id