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Microarray Analysis of microRNA Expression in Basal Cell Carcinoma

NCT ID: NCT01498250

Last Updated: 2012-10-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

7 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-11-30

Study Completion Date

2011-12-31

Brief Summary

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Perturbations in microRNA (miRNA) expression profiles has been reported for a variety of cancers. This study will be an exploratory analysis of miRNA expression in basal cell carcinoma by miRNA expression profiling using microarrays.

Detailed Description

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Perturbations in the expression profiles of microRNAs (miRNAs) have been reported for a variety of different cancers. Basal cell carcinoma (BCC) of the skin has not been systematically evaluated regarding differentially expressed miRNAs. Patients with BCC are included in the study to perform an exploratory analysis by miRNA expression profiling using microarrays. Expression levels of miRNA candidates will be validated by TaqMan real-time quantitative polymerase chain reaction (RT-PCR).

Conditions

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Basal Cell Carcinoma

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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basal cell carcinoma

No interventions assigned to this group

non-lesional skin

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Basal Cell Carcinoma

Exclusion Criteria

* Other Skin Cancer than Basal Cell Carcinoma
Minimum Eligible Age

1 Year

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ruhr University of Bochum

OTHER

Sponsor Role lead

Responsible Party

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Michael Sand

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Falk G Bechara, PD Dr.

Role: STUDY_DIRECTOR

Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum

Peter Altmeyer, Prof. Dr.

Role: STUDY_CHAIR

Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum

Michael Sand, Dr.

Role: PRINCIPAL_INVESTIGATOR

Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum

Locations

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Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum

Bochum, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

References

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Sand M, Skrygan M, Sand D, Georgas D, Hahn SA, Gambichler T, Altmeyer P, Bechara FG. Expression of microRNAs in basal cell carcinoma. Br J Dermatol. 2012 Oct;167(4):847-55. doi: 10.1111/j.1365-2133.2012.11022.x. Epub 2012 Aug 20.

Reference Type RESULT
PMID: 22540308 (View on PubMed)

Other Identifiers

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microRNA6

Identifier Type: -

Identifier Source: org_study_id