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Microarray Analysis of microRNA Expression Profiles in Cutaneous Squamous Cell Carcinoma

NCT ID: NCT01500954

Last Updated: 2012-10-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

7 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-10-31

Study Completion Date

2011-12-31

Brief Summary

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MicroRNAs (miRNAs) are a novel class of short RNAs which have shown to be dysregulated in a variety of cancers. Data of miRNA expression in cutaneous squamous cell carcinoma (cSCC) is very limited and microarray based genome wide miRNA expression profiles of cSCC have not been investigated so far.

Detailed Description

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Patients with cutaneous SCC were enrolled in the present study. Tumor biopsies were taken from the center of the tumor. Adjacent healthy skin was biopsied as a control (intraindividual control). miRNA expression profiles of specimen were detected by microarray miRNA expression profiling. Microarray results were confirmed by TaqMan real-time quantitative polymerase chain reaction (RT-PCR).

Conditions

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Cutaneous Squamous Cell Carcinoma

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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squamous cell carcinoma

No interventions assigned to this group

non-lesional skin

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* cutaneous squamous cell carcinoma

Exclusion Criteria

* other skin cancer than cutaneous squamous cell carcinoma
Minimum Eligible Age

1 Year

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ruhr University of Bochum

OTHER

Sponsor Role lead

Responsible Party

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Michael Sand

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Falk G Bechara, PD Dr.

Role: STUDY_DIRECTOR

Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum

Peter Altmeyer, Prof. Dr.

Role: STUDY_CHAIR

Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum

Michael Sand, Dr.

Role: PRINCIPAL_INVESTIGATOR

Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum

Locations

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Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum

Bochum, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

References

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Sand M, Skrygan M, Georgas D, Sand D, Hahn SA, Gambichler T, Altmeyer P, Bechara FG. Microarray analysis of microRNA expression in cutaneous squamous cell carcinoma. J Dermatol Sci. 2012 Dec;68(3):119-26. doi: 10.1016/j.jdermsci.2012.09.004. Epub 2012 Sep 13.

Reference Type RESULT
PMID: 23026055 (View on PubMed)

Other Identifiers

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microRNA7

Identifier Type: -

Identifier Source: org_study_id