Salivary LINC00657 as a Diagnostic Biomarker for Oral Squamous Cell Carcinoma

NCT ID: NCT05821179

Last Updated: 2023-04-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

36 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2023-02-25

Brief Summary

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This study was designed to verify the role of salivary LINC00657 as a diagnostic marker in oral squamous cell carcinoma (OSCC) patients as compared to oral lichen planus (OLP) (as an example of oral potentially malignant lesions) and normal individuals, and to show its relation to miR-106a. A total of 36 participants were included.

Detailed Description

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This study was designed to verify the role of salivary LINC00657 as a diagnostic marker in oral squamous cell carcinoma (OSCC) patients as compared to oral lichen planus (OLP) (as an example of oral potentially malignant lesions) and normal individuals, and to show its relation to miR-106a. A total of 36 participants were included, subdivided into 3 groups: Group I: 12 patients diagnosed with OSCC. Group II: 12 patients diagnosed with OLP. Group III: 12 systemically free individuals with no oral mucosal lesions. statistical analysis and ROC analysis were performed

Conditions

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Oral Squamous Cell Carcinoma

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Group I

12 patients diagnosed with OSCC.

No interventions assigned to this group

Group II

12 patients diagnosed with OLP.

No interventions assigned to this group

Group III

12 systemically free individuals with no oral mucosal lesions.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* group I : oral squamous cell carcinoma lesions (OSCC)
* group II: oral lichen planus lesions (OLP)
* group III: systemically healthy volunteers

Exclusion Criteria

* oral lesions other than OSCC / OLP in group I and II
* any oral lesion in group III
* pregnant females
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Fayoum University

OTHER

Sponsor Role lead

Responsible Party

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Nayroz Tarrad

associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nayroz Tarrad, as. professor

Role: PRINCIPAL_INVESTIGATOR

faculty of dentistry, Fayoum university

Locations

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faculty of dentistry, Fayoum university

Al Fayyum, , Egypt

Site Status

Countries

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Egypt

References

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Tarrad NAF, Hassan S, Shaker OG, AbdelKawy M. "Salivary LINC00657 and miRNA-106a as diagnostic biomarkers for oral squamous cell carcinoma, an observational diagnostic study". BMC Oral Health. 2023 Dec 12;23(1):994. doi: 10.1186/s12903-023-03726-0.

Reference Type DERIVED
PMID: 38087258 (View on PubMed)

Other Identifiers

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M1

Identifier Type: -

Identifier Source: org_study_id

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