Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx
NCT ID: NCT00899340
Last Updated: 2013-04-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
54 participants
OBSERVATIONAL
2006-05-31
2008-03-31
Brief Summary
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PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.
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Detailed Description
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* To investigate if some of the differences in gene expression are also reflected at the protein level.
* To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance.
* To identify targets for therapy.
OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.
Conditions
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Study Design
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CASE_ONLY
RETROSPECTIVE
Interventions
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gene expression analysis
profiles of HPV(+) and (-) HNSCCs
microarray analysis
microarray analysis
protein expression analysis
protein expression analysis
immunohistochemistry staining method
immunohistochemistry staining method
laboratory biomarker analysis
laboratory biomarker analysis
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Tumor tissue samples available from Vanderbilt Head and Neck Tumor Repository and Vanderbilt Pathology archives
Exclusion Criteria
PRIOR CONCURRENT THERAPY:
* Not specified
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
Vanderbilt-Ingram Cancer Center
OTHER
Responsible Party
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Barbara Murphy, MD
Professor of Medicine, Medical Oncologist
Principal Investigators
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Barbara Murphy, MD
Role: STUDY_CHAIR
Vanderbilt-Ingram Cancer Center
Other Identifiers
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VU-VICC-HN-0624
Identifier Type: -
Identifier Source: secondary_id
VU-VICC-IRB-060380
Identifier Type: -
Identifier Source: secondary_id
VICC HN 0624
Identifier Type: -
Identifier Source: org_study_id
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