Profiling and Targeting Epigenetic Marks to Improve Diagnosis and Therapeutic Approaches in Head and Neck Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-03-06

Study Completion Date

2030-04-04

Brief Summary

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Investigators have recently shown that epigenetic remodelling enzymes, such as HDAC inhibitors, are feasible drugs in HNC (8, 9). Preliminary data are indicating some deregulated epigenetics marks suggesting the corresponding histone modifiers as possible targets for the treatment of HNC, providing an attractive and feasible option to build upon. Our overarching hypothesis is that unique histone marks distinguish HPV+ and HPV- HNC and that specific histone modifiers are novel mediators of HNC tumorigenesis in an HPV specific manner

Detailed Description

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Head and neck cancer (HNC) is a highly heterogeneous disease, involving diverse anatomical sites including oral cavity, larynx and oropharynx. HNC risk factors include tobacco smoking and alcohol consumption and, especially for the subtype of oropharyngeal cancers (OPC), human papillomavirus (HPV) infection

Conditions

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Head and Neck Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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patient with head and neck SCC

Anatomic location: oral cavity, larynx, oropharynx

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Sex: Both male and female
* Human papilloma virus (HPV) test: Both positive and negative.
* Tumor: primary tumors, treatment naïve, squamous cell carcinoma
* Cancer stage: I-IV
* Anatomic location: oral cavity, larynx, oropharynx
* Tumor fragments not required for diagnostics

Exclusion Criteria

* Previous radiotherapy, chemotherapy or immunotherapy for HNC
* Unable to provide written informed consent

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Susanna Chiocca

Role: PRINCIPAL_INVESTIGATOR

Istituto Europeo di Oncologia

Locations

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European Institute of oncology

Milan, MI, Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Susanna Chiocca, Doctor

Role: CONTACT

[email protected]

00390257488835

francesca lombardi, dr