Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors
NCT ID: NCT01572467
Last Updated: 2016-07-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
50 participants
OBSERVATIONAL
2012-04-30
Brief Summary
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PURPOSE: This research trial is studying genes in tumor samples from younger patients with ovarian or testicular sex cord stromal tumors.
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Detailed Description
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* To assess the role of DICER1 mutations and miRNA pathways in the etiology and progression of ovarian or testicular sex cord stromal tumors.
OUTLINE: Archived tumor tissue samples are analyzed for D1CER1 mutation and mRNA expression by reverse-transcriptase polymerase chain reaction (RT-PCR) and laser micro dissector. Results are then correlated with medical data, including age at diagnosis, diagnosis, pathology report, presenting symptoms, family history, treatment, outcome, and length of follow-up, when available.
Conditions
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Study Design
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CASE_ONLY
RETROSPECTIVE
Interventions
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RNA analysis
gene expression analysis
mutation analysis
reverse transcriptase-polymerase chain reaction
laboratory biomarker analysis
medical chart review
Eligibility Criteria
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Inclusion Criteria
* Fixed and frozen tissue samples from the ATBR01 B1 tissue bank and from the International Pleuropulmonary Blastoma Registry, Children's Hospital of Boston, and Massachusetts General Hospital
* Tissue samples from patients diagnosed with:
* Ovarian
* Sertoli-Leydig cell tumor
* Juvenile granulosa cell tumor
* Adult granulosa cell tumor
* Gynandroblastoma
* Sex cord stromal tumor with annular tubules
* Sex cord stromal tumor, undifferentiated
* Sertoli tumor
* Leydig tumor
* Testicular:
* Granulosa cell tumor
* Sertoli tumor
* Leydig tumor
* Sertoli-Leydig
* Undifferentiated stromal tumor
PATIENT CHARACTERISTICS:
* Not specified
PRIOR CONCURRENT THERAPY:
* Not specified
120 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK
Responsible Party
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Principal Investigators
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Dana A. Hill, MD
Role: PRINCIPAL_INVESTIGATOR
Children's National Research Institute
Other Identifiers
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COG-ARAR12B2
Identifier Type: OTHER
Identifier Source: secondary_id
NCI-2012-00721
Identifier Type: REGISTRY
Identifier Source: secondary_id
ARAR12B2
Identifier Type: OTHER
Identifier Source: secondary_id
ARAR12B2
Identifier Type: -
Identifier Source: org_study_id
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