Studying Genes in Samples From Younger Patients With Desmoplastic Small Round Cell Tumor Registered on COG-D9902 or COG-ABTR01B1
NCT ID: NCT01430637
Last Updated: 2016-05-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
20 participants
OBSERVATIONAL
2011-09-30
Brief Summary
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PURPOSE: This research study is studying genes in samples from younger patients with desmoplastic small round cell tumor registered on COG-D9902 or COG-ABTR01B1.
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Detailed Description
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* To perform whole-exome sequencing on desmoplastic small round cell tumor (DSRCT) samples and their available matched normal samples to identify novel mutations, single nucleotide polymorphisms, or copy number changes associated with these tumors.
* To identify regions of interest that may be involved in the pathogenesis (including the region of EWSR1-WT1 translocation) from the whole-exome sequencing and perform detailed resequencing and transcriptone sequencing to further define the molecular aberrations at the RNA level.
OUTLINE: This is a multicenter study.
Archived tumor tissue samples are analyzed for DNA sequencing, effects of RNA on gene expression levels, novel RNA isoforms, splice variants, and translocations.
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Interventions
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DNA analysis
RNA analysis
gene expression analysis
mutation analysis
nucleic acid sequencing
polymerase chain reaction
laboratory biomarker analysis
pharmacogenomic studies
Eligibility Criteria
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Inclusion Criteria
* Tumor and blood samples from patients registered on COG-D9902 or COG-ABTR01B1 obtained from the Cooperative Human Tissue Network (CHTN) and the Children's Oncology Group (COG) tumor banks
* Matched normal samples
PATIENT CHARACTERISTICS:
* Not specified
PRIOR CONCURRENT THERAPY:
* Not specified
50 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK
Responsible Party
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Principal Investigators
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Pooja Hingorani, MD
Role: PRINCIPAL_INVESTIGATOR
Phoenix Children's Hospital
Other Identifiers
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COG-ARST11B5
Identifier Type: OTHER
Identifier Source: secondary_id
ARST11B5
Identifier Type: OTHER
Identifier Source: secondary_id
NCI-2011-03455
Identifier Type: REGISTRY
Identifier Source: secondary_id
ARST11B5
Identifier Type: -
Identifier Source: org_study_id
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