Blood Flow Restriction Resistance Exercise and Cardiac Cycle Dynamics

NCT ID: NCT07344740

Last Updated: 2026-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-02-01

Study Completion Date

2028-01-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Blood flow restriction resistance exercise uses partial vascular occlusion of a limb during low weight resistance exercises to stimulate muscle strengthening and growth. This is commonly used during rehabilitation from an injury. Because blood flow in and out of the limbs is decreased, this may have consequences for blood flow through the heart. The purpose of this study will be to test cardiac dynamics during blood flow restriction resistance exercise to determine if cardiac blood flow is impacted. It is hypothesized that both non-BFR exercise and BFR exercise will increase heart rate shortening various cardiac cycle parameters, but BFR exercise will increase the isovolumetric contraction time vs non-BFR exercise due to an increase in total peripheral resistance. It is also hypothesized that BFR exercise will lower early ventricular filling parameters due to lower venous return.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cardiac

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Intervention group

Blood flow restriction resistance exercise

Group Type EXPERIMENTAL

Blood flow restriction resistance exercise

Intervention Type OTHER

Blood flow in and out of the limb will be artificially with an occlusion cuff.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Blood flow restriction resistance exercise

Blood flow in and out of the limb will be artificially with an occlusion cuff.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Generally healthy

Exclusion Criteria

* Uncontrolled hypertension
* Peripheral vascular disease
* Lymphedema
* Sickle cell anemia
* Heart failure
* Stroke history
* Heart attack history
* Rheumatoid arthritis
* Chronic kidney disease
* Diabetes
* Severe neuropathy
* Any condition that may make blood flow restriction resistance exercise riskier like history of blood clots
* Use of coagulant therapy
* Susceptible to blood clots
* Obesity
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Montclair State University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Montclair State University

Montclair, New Jersey, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Evan Matthews

Role: CONTACT

17406328709

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Francine Seruya

Role: primary

973-655-7583

Kim Blatt

Role: backup

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

IRB-FY25-26-5034

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.