Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
72 participants
INTERVENTIONAL
2020-11-23
2021-11-26
Brief Summary
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Detailed Description
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However, there is still huge heterogeneity in training intervention design, also there still lacks studies to further elucidate the effects of high intensity resistance training combined with aerobic training on physical performance (aerobic capacity, muscle strength, balance), body composition, quality of life, morbidity, mortality, etc. Therefore, the aim of this study was to examine the effects of high (70%-80 % 1-RM) versus low loads (30%- 40 % 1-RM) resistance training in combination with aerobic interval cycling (50 % -80% of baseline peak Power output) in coronary artery disease patients and patients with heart failure.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Aerobic interval training with high loads resistance training
Patient to be randomised into "combined aerobic training with high loads resistance training group".
Aerobic interval training combined with high intensity resistance training
Patients enrolled in arm of the study will perform 12 weeks of combined aerobic interval training (5 intervals of cycling at the intensity of 50 %-80% of peak power obtained at baseline cardiopulmonary testing) combined with high intensity resistance training (3 sets of leg press at the intensity of 70 %- 80 % of one repetition maximum (1-RM)).
Aerobic interval training with low loads resistance training
Patient to be randomised into "combined aerobic training with low loads resistance training group".
Aerobic interval training combined with low intensity resistance training
Patients enrolled in arm of the study will perform 12 weeks of combined aerobic interval training (5 intervals of cycling at the intensity of 50 %-80% of peak power obtained at baseline cardiopulmonary testing) combined with high intensity resistance training (3 sets of leg press at the intensity of 30 %- 40 % 1-RM).
Aerobic interval training
Patient to be randomised into "aerobic training training group".
Aerobic interval training
Patients enrolled in arm of the study will perform 12 weeks of aerobic interval training (5 intervals of cycling at the intensity of 50 %-80% of peak power obtained at baseline cardiopulmonary testing).
Interventions
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Aerobic interval training combined with high intensity resistance training
Patients enrolled in arm of the study will perform 12 weeks of combined aerobic interval training (5 intervals of cycling at the intensity of 50 %-80% of peak power obtained at baseline cardiopulmonary testing) combined with high intensity resistance training (3 sets of leg press at the intensity of 70 %- 80 % of one repetition maximum (1-RM)).
Aerobic interval training combined with low intensity resistance training
Patients enrolled in arm of the study will perform 12 weeks of combined aerobic interval training (5 intervals of cycling at the intensity of 50 %-80% of peak power obtained at baseline cardiopulmonary testing) combined with high intensity resistance training (3 sets of leg press at the intensity of 30 %- 40 % 1-RM).
Aerobic interval training
Patients enrolled in arm of the study will perform 12 weeks of aerobic interval training (5 intervals of cycling at the intensity of 50 %-80% of peak power obtained at baseline cardiopulmonary testing).
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Stable Heart Failure patients with documented reduced ejection fraction (\>40-45 %)
* age \>18 years
* NYHA class I-III
* Cardiopulmonary exercise test without ECG abnormalities
Exclusion Criteria
* Decompensated HF
* Uncontrolled arrhythmias
* Severe and symptomatic aortic stenosis
* Acute myocarditis, endocarditis, or pericarditis
* Aortic dissection
* Marfan syndrome
* Musculoskeletal limitations
18 Years
ALL
Yes
Sponsors
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University of Ljubljana
OTHER
University of Primorska
OTHER
General Hospital Murska Sobota
OTHER
Responsible Party
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Principal Investigators
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Mitja Lainščak, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
General Hospital Murska Sobota; University of Ljubljana, Faculty of Medicine
Tim Kambič, MKin
Role: PRINCIPAL_INVESTIGATOR
General Hospital Murska Sobota; University of Ljubljana, Faculty of Sport
Locations
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Division of Cardiology, General Hospital Murska Sobota
Murska Sobota, , Slovenia
Countries
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Central Contacts
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Facility Contacts
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Mitja Lainščak, MD, PhD
Role: primary
Tim Kambič, MKin
Role: backup
References
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Kambic T, Bozic Mijovski M, Jug B, Hadzic V, Lainscak M. Insulin resistance, lipids and body composition in patients with coronary artery disease after combined aerobic training and resistance training: a randomised, controlled trial. Diabetol Metab Syndr. 2023 Mar 15;15(1):47. doi: 10.1186/s13098-023-01017-w.
Kambic T, Sarabon N, Hadzic V, Lainscak M. Physical activity and sedentary behaviour following combined aerobic and resistance training in coronary artery disease patients: A randomised controlled trial. Int J Cardiol. 2023 Jan 1;370:75-79. doi: 10.1016/j.ijcard.2022.10.157. Epub 2022 Oct 29.
Kambic T, Sarabon N, Lainscak M, Hadzic V. Combined resistance training with aerobic training improves physical performance in patients with coronary artery disease: A secondary analysis of a randomized controlled clinical trial. Front Cardiovasc Med. 2022 Aug 24;9:909385. doi: 10.3389/fcvm.2022.909385. eCollection 2022.
Kambic T, Sarabon N, Hadzic V, Lainscak M. Effects of high-load and low-load resistance training in patients with coronary artery disease: rationale and design of a randomised controlled clinical trial. BMJ Open. 2021 Jul 22;11(7):e051325. doi: 10.1136/bmjopen-2021-051325.
Kambic T, Hadzic V, Lainscak M. Hemodynamic Response to High- and Low-Load Resistance Exercise in Patients with Coronary Artery Disease: A Randomized, Crossover Clinical Trial. Int J Environ Res Public Health. 2021 Apr 8;18(8):3905. doi: 10.3390/ijerph18083905.
Other Identifiers
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GH-MS-CVD-RT
Identifier Type: -
Identifier Source: org_study_id