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Eccentric Cycling Exercise During Pulmonary Rehabilitation Pulmonary Vascular Disease

NCT ID: NCT06480656

Last Updated: 2024-06-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-05-29

Study Completion Date

2026-07-01

Brief Summary

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Eccentric cycling allows high intensities with low metabolic costs. Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD

Detailed Description

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Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD). For these patients, regular exercise training has an evidence level 1A recommendation in the current guidelines. Exercise training during longer and regular periods provides chronic adaptation, for which ECC was recently found to have a greater effectiveness than CON by increasing muscle strength, hypertrophy, six-minute walking distance and furthermore, by increasing maximum oxygen uptake (V'O2max) especially in patients with chronic obstructive pulmonary disease (COPD), chronic left heart failure or coronary heart disease.

Furthermore, the investigators conducted an RCT in which the investigators exposed patients with PVD to ECC and concluded that ECC is a feasible and well-tolerated exercise modality for PVD patients with severely lower O2 demand and load to the right ventricle.

Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD.

Conditions

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Eccentric Cycling Exercise

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Eccentric cycling exercise

Group Type EXPERIMENTAL

Rehabilitation with eccentric cycling exercise

Intervention Type PROCEDURE

Instead of normal cycling, patients will exercise on the eccentric bike.

Concentric cycling exercise

Group Type ACTIVE_COMPARATOR

normal rehabilitation

Intervention Type PROCEDURE

Normal rehabilitation will be conducted

Interventions

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Rehabilitation with eccentric cycling exercise

Instead of normal cycling, patients will exercise on the eccentric bike.

Intervention Type PROCEDURE

normal rehabilitation

Normal rehabilitation will be conducted

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Diagnosed with PVD, either PAH or CTEPH according to recent guidelines
* Stable medication for at least 1 month
* Age 18 to 85 years
* No resting hypoxemia (PaO2 \>7.3kPa)

Exclusion Criteria

* Any co-morbidity that limits the patient to participate the full rehabilitation
* Enrollments in other trials with active treatments
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Silvia Ulrich Somaini

Prof. Dr. med.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Rehabilitation clinic Barmelweid

Erlinsbach, , Switzerland

Site Status RECRUITING

University Hospital Zurich, Pneumology

Zurich, , Switzerland

Site Status RECRUITING

Countries

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Switzerland

Central Contacts

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Silvia Ulrich, Prof

Role: CONTACT

Phone: 0442564362

Email: [email protected]

Julian Müller, Msc

Role: CONTACT

Phone: 0432539349

Email: [email protected]

Facility Contacts

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Thomas Sidrist, md

Role: primary

Other Identifiers

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EccRehab

Identifier Type: -

Identifier Source: org_study_id