Active and Passive Exercise Training in Improving Vascular Function: Local vs Systemic Vascular Effect.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-01

Study Completion Date

2024-12-31

Brief Summary

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Maintaining an adequate state of vascular function is an important element for the maintenance of cardiovascular well-being. Several training plans involving both active and passive engagement by the muscles have been proposed with the aim of improving vascular function. At local level, i.e., at the level of the arteries that supply the muscles directly involved in training, significant improvements in vascular function have been found. These improvements are more noticeable after active training than with a passive training regimen, such as passive static stretching. On the contrary, at the systemic level the effects of active or passive training are less clear and, above all, it is not evident whether there is a difference in the effects induced at the level of vascular function in arteries supplying muscles not directly involved in training. The aim of the study is to clarify the local and systemic effect of an active training protocol (single leg knee extension, SLKE) and of a passive training protocol (passive static stretching training, PST) applied to the lower limbs lasting 8 weeks on the local (femoral artery) and systemic (brachial artery) vascular function.

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Detailed Description

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Conditions

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Aerobic Exercise Stretching

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Three arms: 1) active exercise training (single leg knee extension); 2) passive exercise training (passive static training); 3) controls (no training)

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

Blind to intervention

Study Groups

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Control (CTRL)

CTRL will not receive any intervention.

Group Type NO_INTERVENTION

No interventions assigned to this group

Single leg knee extension training (SLKE)

Active 8-week training involving lower limbs. SLKE participants will be involved in a 8-week aerobic training protocol involving the knee extensor muscles. The training will be held on an Anderson and Saltin ergometer, 3 times per week, with a single session duration of 33.3 min. Total weekly duration: 100 min.

Group Type EXPERIMENTAL

Training

Intervention Type OTHER

8-weeks iso-volume active (SLKE) or passive static stretching training (PST) involving lower limb muscles

Passive static stretching training (PST)

Passive 8-week training involving lower limbs. PST participants will be involved in a 8-week passive static training training involving the knee extensor muscles. The training will have a frequency of 5 times per week, with a single duration of 20 min. Total weekly duration: 100 min

Group Type ACTIVE_COMPARATOR

Training

Intervention Type OTHER

8-weeks iso-volume active (SLKE) or passive static stretching training (PST) involving lower limb muscles

Interventions

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Training

8-weeks iso-volume active (SLKE) or passive static stretching training (PST) involving lower limb muscles

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

\-

Exclusion Criteria

* neurological, vascular and musculoskeletal disorders of the lower and upper limbs;
* being on pharmacological therapy related to either neural and/or vascular response, including hormonal contraceptives and oral supplements;
* being a current or former smoker;
* having an irregular menstrual cycle (26 to 35 days) up to 3 months before the beginning of the study;
* contraindications to joint mobilization; regular involvement in a SLKE or PS training programme.

Minimum Eligible Age

20 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes