The Effects of Aerobic Exercise in Microvascular Endothelium Function in Patients With Cardiovascular Diseases

NCT ID: NCT02514564

Last Updated: 2017-03-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

115 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-12-31

Study Completion Date

2016-12-31

Brief Summary

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This study evaluates the effects of different volumes of aerobic exercise training in cardiovascular parameters of patients with cardiovascular diseases enrolled in a cardiac rehabilitation program.

Detailed Description

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Aerobic exercise training is well known to improve endothelium dependent vasodilatation in the microcirculation. However, the impact of exercise frequency on this response in patients with coronary artery disease remains unclear.

Conditions

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Cardiovascular Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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2x/wk

This group will be consisted of patients that will perform exercise two times a week.

Exercise

Intervention Type BEHAVIORAL

Patients included in the study will be enrolled in a cardiac rehabilitation program, in an independent manner of the study protocols.

3x/wk

This group will be consisted of patients that will perform exercise three times a week.

Exercise

Intervention Type BEHAVIORAL

Patients included in the study will be enrolled in a cardiac rehabilitation program, in an independent manner of the study protocols.

Control

This group will not perform exercise.

No interventions assigned to this group

Interventions

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Exercise

Patients included in the study will be enrolled in a cardiac rehabilitation program, in an independent manner of the study protocols.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* sedentarism for at least 6 months;
* clinical diagnosis for coronary artery disease (occurrence of any acute coronary syndrome, including ST elevation or non-ST elevation myocardial infarction or unstable angina or by the diagnosis of obstructive coronary artery disease on coronary angiography in patients with stable angina).

Exclusion Criteria

* nephropathies;
* decompensated cardiovascular diseases;
* liver diseases.
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Instituto Nacional de Cardiologia de Laranjeiras

OTHER

Sponsor Role lead

Responsible Party

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Juliana Pereira Borges

PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Eduardo V TibiriƧƔ, PhD

Role: STUDY_DIRECTOR

Instituto Fernandes Figueira

Locations

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Instituto Nacional de Cardiologia

Rio de Janeiro, Rio de Janeiro, Brazil

Site Status

Countries

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Brazil

References

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Souza EG, De Lorenzo A, Huguenin G, Oliveira GM, Tibirica E. Impairment of systemic microvascular endothelial and smooth muscle function in individuals with early-onset coronary artery disease: studies with laser speckle contrast imaging. Coron Artery Dis. 2014 Jan;25(1):23-8. doi: 10.1097/MCA.0000000000000055.

Reference Type BACKGROUND
PMID: 24172594 (View on PubMed)

Cordovil I, Huguenin G, Rosa G, Bello A, Kohler O, de Moraes R, Tibirica E. Evaluation of systemic microvascular endothelial function using laser speckle contrast imaging. Microvasc Res. 2012 May;83(3):376-9. doi: 10.1016/j.mvr.2012.01.004. Epub 2012 Jan 31.

Reference Type BACKGROUND
PMID: 22326551 (View on PubMed)

Borges JP, Mediano MF, Farinatti P, Coelho MP, Nascimento PM, Lopes GO, Kopiler DA, Tibirica E. The Effects of Unsupervised Home-based Exercise Upon Functional Capacity After 6 Months of Discharge From Cardiac Rehabilitation: A Retrospective Observational Study. J Phys Act Health. 2016 Nov;13(11):1230-1235. doi: 10.1123/jpah.2016-0058. Epub 2016 Aug 24.

Reference Type DERIVED
PMID: 27333938 (View on PubMed)

Other Identifiers

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Faperj-E-26/101.575

Identifier Type: -

Identifier Source: org_study_id

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