Optimization of Interval Exercise Based-intensity on Ventilatory Anaerobic Threshold in Coronary Artery Disease
NCT ID: NCT02313831
Last Updated: 2014-12-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
68 participants
INTERVENTIONAL
2013-08-31
2015-12-31
Brief Summary
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Detailed Description
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Objective:To investigate the effects of interval training, based-intensity on 70% at 110% of oxygen consumption and workload attained on ventilatory anaerobic threshold, on aerobic functional capacity, autonomic modulation of heart rate, metabolic profile in patients with and without coronary artery disease.
Design: Prospective randomized controlled trial. Subjects: 68 men between 40 and 65 years old.
All subjects will be submitted:
1. \- Clinical assessment: personal data, lifestyle and food, family history, current and previous history of disease.
2. \- Physical examination: cardiac and lung auscultation,measurement of heart rate, blood pressure, body weight and height.
3. \- Heart rate will be recorded at rest, in the supine position for 15 min, standing position for 10 min and respiratory sinus arrhythmia maneuver.
4. \- Submaximal or symptom-limited cardiopulmonary exercise test on cycle ergometer will be performed to determined the ventilatory anaerobic threshold.
5. \- Two cardiopulmonary exercise testing on treadmill at constant workload (moderate and high intensity). Expiratory flow limitation will be evaluated by flow-volume loops at the end of each exercise workload.
6. \- Blood samples will be collected to analyze glycemic and lipid profiles.
7. \- After these procedures, the subjects will be randomly assigned to one of two groups, trained group or control group.
8. \- Interval training program will consist 30-40 minutes each exercise session, three times a week for 16 weeks, with a workload determined on the basis of ventilatory anaerobic threshold.
9. \- At 48 hours after the last day of training, the subjects will repeat all experimental procedures as in baseline testing. Controls will be retested 16 weeks after the completion of baseline testing.
10. \- All subjects will be instructed to maintain their habitual diet without a standardized caloric restriction.
Thus, it is expected that interval training will promote beneficial physiological adaptations in patients with and without coronary artery disease.
Conditions
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Keywords
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Study Design
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RANDOMIZED
SINGLE_GROUP
TREATMENT
DOUBLE
Study Groups
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Exercise training
Patients of this group will be submitted to an interval training
Interval training
Patients of this group will be submitted to an interval training program
Interventions
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Interval training
Patients of this group will be submitted to an interval training program
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* After this procedure, the CAD+ group will include 34 patients, who will have clinical evidence significant stenosis (\<50% of stenosis in one or more major coronary vessels), or previous coronary artery intervention (such as percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery).
* The CAD- group will be comprised 32 patients without stenosis in coronary vessels (angiographically documented) and without history of previous myocardial infarction (MI), PCI or CABG.
* All the patients will have three or more cardiovascular risk factors such as obesity (body mass index \>30 kg/m2), smoking, sedentary lifestyle according to the International Physical Activity Questionnaire (IPAQ) version 6, hypertension, diabetes mellitus (type 2 - nonusers of insulin), and dyslipidemia.
Exclusion Criteria
* Chronic obstructive pulmonary disease
* Unstable angina
* Osteomuscular disorders
* Diabetes mellitus (users of insulin)
* Renal failure
* Sequelae associated with stroke.
40 Years
65 Years
MALE
No
Sponsors
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Universidade Federal de Sao Carlos
OTHER
Responsible Party
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Nayara Yamada Tamburús
M.D.
Principal Investigators
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Ester d Silva, PhD
Role: PRINCIPAL_INVESTIGATOR
Universidade Federal de Sao Carlos
Locations
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Nayara Yamada Tamburús
São Carlos, São Paulo, Brazil
Countries
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Central Contacts
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Facility Contacts
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Nayara Y Tamburus, M.D.
Role: primary
Ester Silva, PhD
Role: backup
References
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Tamburus NY, Verlengia R, Kunz VC, Cesar MC, Silva E. Apolipoprotein B and angiotensin-converting enzyme polymorphisms and aerobic interval training: randomized controlled trial in coronary artery disease patients. Braz J Med Biol Res. 2018;51(8):e6944. doi: 10.1590/1414-431x20186944. Epub 2018 May 28.
Tamburus NY, Kunz VC, Salviati MR, Castello Simoes V, Catai AM, Da Silva E. Interval training based on ventilatory anaerobic threshold improves aerobic functional capacity and metabolic profile: a randomized controlled trial in coronary artery disease patients. Eur J Phys Rehabil Med. 2016 Feb;52(1):1-11. Epub 2015 Jun 18.
Other Identifiers
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34/2012
Identifier Type: -
Identifier Source: org_study_id