Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease

NCT ID: NCT02450318

Last Updated: 2023-06-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

7 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-06-30

Study Completion Date

2023-04-14

Brief Summary

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The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease.

Detailed Description

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Women are more likely to have nonobstructive coronary artery disease (CAD) . The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease. Endothelium-dependent and -independent dilation, arterial stiffness and wave reflection will be measured at baseline and after walking on a treadmill at a slow pace for 47 minutes. Endothelium-dependent dilation will be measured using brachial artery flow-mediated dilation via high resolution ultrasonography. Endothelium-independent dilation will be measured using brachial artery dilation to sublingual nitroglycerin. Arterial stiffness and wave reflection will measured using applanation tonometry.

Conditions

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Nonobstructive Coronary Artery Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Slow-paced walking

Subjects will complete 47 minutes of walking at slow pace.

Group Type EXPERIMENTAL

Slow-paced walking

Intervention Type OTHER

Subjects will walk on a treadmill at a slow pace for 47 minutes

Interventions

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Slow-paced walking

Subjects will walk on a treadmill at a slow pace for 47 minutes

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* women with non-obstructive coronary artery disease documented within the past 5 years by coronary angiogram as no coronary arteries with stenosis greater than 50% lesions
* age 18 to 89 years
* able to complete maximal graded exercise test

Exclusion Criteria

* use of tobacco products within the previous six months
* use of oral contraceptives or hormone replacement therapy within the prior year
* pregnancy (positive urine pregnancy test) or lactation
* history of hepatic disease or infection with hepatitis B, C or HIV
Minimum Eligible Age

18 Years

Maximum Eligible Age

89 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University of Florida

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Demetra Christou, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Florida

Locations

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Integrative Cardiovasculal Physiology Laboratory

Gainesville, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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IRB201500077

Identifier Type: -

Identifier Source: org_study_id

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