Effects of Spinal vs General Anesthesia on Systemic Inflammation in PCNL

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-10-15

Study Completion Date

2026-04-15

Brief Summary

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This observational study aims to compare the effects of spinal and general anesthesia on perioperative systemic inflammatory response in patients undergoing percutaneous nephrolithotomy (PCNL). Systemic inflammatory indices derived from routine complete blood count parameters, including Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), Neutrophil-to-Lymphocyte Ratio (NLR), and Red Cell Distribution Width (RDW), will be evaluated. Preoperative and postoperative laboratory values will be analyzed to determine whether the type of anesthesia influences systemic inflammatory markers and related clinical outcomes.

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Detailed Description

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Conditions

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Anesthesia Techniques Percutaneous Nephrolithotomy Systemic Inflammation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Spinal Anesthesia Group

Patients undergoing percutaneous nephrolithotomy under spinal anesthesia as part of routine clinical practice. No additional intervention is performed for the purposes of the study.

No interventions assigned to this group

General Anesthesia Group

Patients undergoing percutaneous nephrolithotomy under general anesthesia as part of routine clinical practice. No additional intervention is performed for the purposes of the study.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* American Society of Anesthesiologists (ASA) physical status class I-III
* Patients aged 18 years and older

Exclusion Criteria

* American Society of Anesthesiologists (ASA) physical status class IV or V
* Patients younger than 18 years
* Active infection or diagnosis of sepsis
* Malignancy
* Chronic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus)
* Use of immunosuppressive therapy
* Pregnancy

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No