NLR and Sevoflurane Use in Ear Surgeries: Flow Comparison

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-07-20

Study Completion Date

2023-09-20

Brief Summary

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This retrospective study aims to compare the effects of low-flow and high-flow anesthesia techniques on intraoperative hemodynamics, neutrophil-to-lymphocyte ratio (NLR), and postoperative outcomes in patients undergoing tympanoplasty or myringoplasty. The data were collected from medical records of patients who underwent ear surgery between \[September 1, 2022\] and \[April 1, 2023\]. The study seeks to evaluate whether the choice of anesthetic flow rate has a significant impact on inflammatory response and recovery.

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Detailed Description

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This study investigates the influence of anesthetic gas flow rates on systemic inflammation and hemodynamic stability in middle ear surgeries. While low-flow anesthesia is associated with reduced environmental exposure and cost-effectiveness, its impact on inflammatory markers and recovery outcomes remains less clearly defined. The neutrophil-to-lymphocyte ratio (NLR) is used as a readily available, cost-effective biomarker of systemic inflammation. This study retrospectively analyzes perioperative data from patients who underwent tympanoplasty or myringoplasty, comparing NLR levels, intraoperative vital signs, and postoperative recovery parameters between low-flow and high-flow anesthesia groups. The results may contribute to optimizing anesthetic strategies in otologic surgeries, with emphasis on inflammation modulation and patient safety.

Conditions

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Tympanoplasty Myringoplasty Neutrophil-to-Lymphocyte Ratio Low-flow Anesthesia High-flow Anesthesia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Low-flow anesthesia group

Low-flow anesthesia group 0.75 L/min :

Patients who underwent tympanoplasty or myringoplasty under low-flow anesthesia technique. The anesthetic gas flow rate was maintained at low levels throughout the procedure to evaluate its effects on systemic inflammation and hemodynamics.

No interventions assigned to this group

High-flow anesthesia group

High-flow anesthesia group 3 L/min :

Patients who underwent tympanoplasty or myringoplasty under high-flow anesthesia technique. The anesthetic gas flow rate was maintained at high levels throughout the procedure to compare its impact on inflammatory response and postoperative outcomes.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Adults aged between 18 and 75 years
* American Society of Anesthesiologists (ASA) physical status classification I to III
* Body Mass Index (BMI) between 18.5 and 29.9 kg/m²

Exclusion Criteria

* Age below 18 or above 75 years
* Incomplete or missing clinical data
* BMI less than 18.5 kg/m² or greater than 29.9 kg/m²
* Presence of neurological disorders
* History of renal or hepatic failure

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No