Inflammatory Response Under Spinal vs General Anesthesia in PCNL: NLR, RDW, LAR.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-09-22

Study Completion Date

2025-10-22

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This observational study compares the effects of spinal versus general anesthesia on the perioperative systemic inflammatory response in adults undergoing PCNL. Routine clinical laboratory values (NLR, RDW, LAR) obtained preoperatively and postoperatively will be recorded to evaluate between-group and within-group changes. No additional blood sampling will be performed beyond standard care.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of Spinal vs General Anesthesia on Systemic Inflammation in PCNL

NCT07326670

Anesthesia Techniques Percutaneous Nephrolithotomy Systemic Inflammation

RECRUITING

The Effect of Preoperative NLR Level on Epidural Analgesia Application in Thoracotomy

NCT05209958

C23.550.767.700 C23.550.470

COMPLETED

Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio

NCT05628935

Inflammation Anesthesia

COMPLETED

Spinal Versus General Anesthesia and Inflammatory Response Measured by Delta Neutrophil Index in Total Knee Arthroplasty: An Observational Study

NCT07214558

Inflammatory Response in Total Knee Arthroplasty

COMPLETED

NLR and Sevoflurane Use in Ear Surgeries: Flow Comparison

NCT07064642

Tympanoplasty Myringoplasty Neutrophil-to-Lymphocyte Ratio +2 more

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The study will be conducted at the Department of Anesthesiology and Reanimation, Elazığ Fethi Sekin City Hospital, among adult patients scheduled for PCNL (ASA I-III). The anesthesia type (spinal vs general) is determined by clinical requirements; investigators do not influence this choice.

Sampling windows:

Preoperative: within ≤6 hours before surgery

Postoperative: first sample obtained within 6-24 hours after surgery Parameters: NLR (neutrophil/lymphocyte), RDW, LAR; plus age, sex, ASA class, operative time, and in-hospital complications.

Statistics: Normality testing; between-group comparisons by independent t-test or Mann-Whitney U; within-group by paired t-test or Wilcoxon; categorical by chi-square; p\<0.05 significant. Power considerations target ≥45 per group (total ≥90). No extra biospecimens will be collected beyond routine care.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Nephrolithiasis Postoperative Inflammation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Spinal Anesthesia Cohort

Adult patients (≥18 years, ASA I-III) undergoing percutaneous nephrolithotomy (PCNL) under spinal anesthesia. Routine perioperative laboratory values (NLR, RDW, LAR) will be recorded preoperatively and postoperatively.

Anesthesia Type

Intervention Type OTHER

Patients receive either spinal or general anesthesia according to routine clinical decision-making. No investigational drug or device is administered.

General Anesthesia Cohort

Adult patients (≥18 years, ASA I-III) undergoing percutaneous nephrolithotomy (PCNL) under general anesthesia. Routine perioperative laboratory values (NLR, RDW, LAR) will be recorded preoperatively and postoperatively.

Anesthesia Type

Intervention Type OTHER

Patients receive either spinal or general anesthesia according to routine clinical decision-making. No investigational drug or device is administered.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Anesthesia Type

Patients receive either spinal or general anesthesia according to routine clinical decision-making. No investigational drug or device is administered.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Age ≥18 years

ASA physical status I-III

Scheduled for percutaneous nephrolithotomy (PCNL)

Provided informed consent

Exclusion Criteria

Active infection or sepsis

Known malignancy

Chronic inflammatory or autoimmune disease (e.g., rheumatoid arthritis, systemic lupus erythematosus)

Current immunosuppressive therapy

Pregnancy

Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No