Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
849 participants
OBSERVATIONAL
2020-01-01
2025-05-10
Brief Summary
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Detailed Description
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Conditions
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Study Design
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OTHER
RETROSPECTIVE
Study Groups
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Group S
Underwent total knee arthroplasty under spinal anesthesia
The effects of the groups on perioperative inflammation changes were compared.
Between January 2020 and April 2025, data from 849 patients who underwent total knee arthroplasty were retrospectively reviewed. Preoperative hemogram values were obtained during routine anesthesia clinic evaluation, typically one day prior to surgery. Postoperative hemogram samples were collected on the day of surgery (postoperative day 0), within 4 to 12 hours after the procedure. Blood parameters included neutrophil, lymphocyte, monocyte, and platelet counts. Based on these values, inflammatory indices such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) were calculated.
Group G
Underwent total knee arthroplasty under general anesthesia
The effects of the groups on perioperative inflammation changes were compared.
Between January 2020 and April 2025, data from 849 patients who underwent total knee arthroplasty were retrospectively reviewed. Preoperative hemogram values were obtained during routine anesthesia clinic evaluation, typically one day prior to surgery. Postoperative hemogram samples were collected on the day of surgery (postoperative day 0), within 4 to 12 hours after the procedure. Blood parameters included neutrophil, lymphocyte, monocyte, and platelet counts. Based on these values, inflammatory indices such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) were calculated.
Interventions
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The effects of the groups on perioperative inflammation changes were compared.
Between January 2020 and April 2025, data from 849 patients who underwent total knee arthroplasty were retrospectively reviewed. Preoperative hemogram values were obtained during routine anesthesia clinic evaluation, typically one day prior to surgery. Postoperative hemogram samples were collected on the day of surgery (postoperative day 0), within 4 to 12 hours after the procedure. Blood parameters included neutrophil, lymphocyte, monocyte, and platelet counts. Based on these values, inflammatory indices such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) were calculated.
Eligibility Criteria
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Inclusion Criteria
* Patients with ASA physical status I or II
* Patients who have underwent total knee arthroplasty under general or spinal anesthesia
Exclusion Criteria
* Patients with ASA physical status ≥III
* Patients with severe cardiopulmonary or metabolic disorders, coagulation disorders or active infection
* Patients with known allergies or chronic steroid use
* Patients with incomplete laboratory data
* Patients who underwent revision total knee arthroplasty
* Patients who required intraoperative conversion from spinal to general anesthesia
* Patients with a history of major trauma and/or emergency surgery
18 Years
75 Years
ALL
No
Sponsors
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Tokat Gaziosmanpasa University
OTHER
Responsible Party
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Ali Genc
Assistant professor
Locations
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Tokat Gaziosmanpasa University
Tokat Province, , Turkey (Türkiye)
Countries
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Other Identifiers
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25-MOBAEK-160
Identifier Type: -
Identifier Source: org_study_id
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