The Effect of Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries

NCT ID: NCT04891146

Last Updated: 2021-05-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

84 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-03-05

Study Completion Date

2020-12-12

Brief Summary

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The effects of different anesthesia methods on the immune system are variable. In this study, we investigated the effect of inhalation anesthesia and total intravenous anesthesia on the SII value in major abdominal cancer surgeries.

Detailed Description

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The study was planned prospectively, observationally, on a total of 90 patients who underwent major abdominal cancer surgery. 84 patients were evaluated. The patients were seperated in two groups as inhalation anesthesia and total intravenous anesthesia (TIVA). The demographic data of the patients, type of cancer, type of surgery performed, ASA classification, preoperative chemotherapy intake, preoperative hemogram, postoperative 2nd and 24th hour hemogram, intraoperative and postoperative blood transfusion, and duration of surgery were recorded. Platelet, neutrophil, lymphocyte and SII values were saved.

Conditions

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Systemic Immune Activation Cancer Gi Cancer of Endometrium

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Inhalation anesthesia

Sevoflurane for opioid remifentanyl used

Systemic inflammatory immmune index

Intervention Type OTHER

Systemic Inflammatory Immune index calculated from platelet, neutrophil and lymphocyte count

Total Intravenous Anesthesia

Propofol for opioid remifentanyl used

Systemic inflammatory immmune index

Intervention Type OTHER

Systemic Inflammatory Immune index calculated from platelet, neutrophil and lymphocyte count

Interventions

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Systemic inflammatory immmune index

Systemic Inflammatory Immune index calculated from platelet, neutrophil and lymphocyte count

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* major abdominal cancer surgeries

Exclusion Criteria

* blood transfusion in last 72 hours
* patients with infection
* hematologic malignancy
* patient controlled analgesia
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Arsen Güngör

Anesthesiology and Reanimation Specialist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Arsen Gungor

Role: PRINCIPAL_INVESTIGATOR

[email protected]

Locations

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Dr. Abdurrahman Yurtaslan Oncology Research and Trainee Hospital

Ankara, Yenimahalle, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W, Zhang X, Wang WM, Qiu SJ, Zhou J, Fan J. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014 Dec 1;20(23):6212-22. doi: 10.1158/1078-0432.CCR-14-0442. Epub 2014 Sep 30.

Reference Type RESULT
PMID: 25271081 (View on PubMed)

Lee JH, Kang SH, Kim Y, Kim HA, Kim BS. Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study. Korean J Anesthesiol. 2016 Apr;69(2):126-32. doi: 10.4097/kjae.2016.69.2.126. Epub 2016 Mar 30.

Reference Type RESULT
PMID: 27066202 (View on PubMed)

Other Identifiers

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AbdurrahmanYAOTRH

Identifier Type: -

Identifier Source: org_study_id

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