EFFECT OF ANESTHESİA TECHNIQUES ON POSTOPERATİVE COGNİTİVE DYSFUNCTION FOR MMSE AND NSE LEVEL

NCT ID: NCT04279132

Last Updated: 2020-02-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-03-21

Study Completion Date

2020-07-21

Brief Summary

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The aim of this study is to compare the effects of total intravenous anesthesia and inhalation anesthesia methods on postoperative cognitive dysfunction according to Mini Mental State Examination scores and Neuron Specific Enolase levels in lumbar disc herniectomy operations.

Detailed Description

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Conditions

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Postoperative Cognitive Dysfunction NEURON SPECIFIC ENOLASE MINI MENTAL STATE EXAMINATION TEST

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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TOTAL INTRAVENOUS ANESTHESIA

POSTOPERATIVE COGNITIVE DYSFUNCTION

Intervention Type BEHAVIORAL

NEURON SPECIFIC ENOLASE LEVELS IN LUMBAR DISC HERNIECTOMY WITH GENERAL ANESTHESIA MODALITIES

INHALATION ANESTHESIA

POSTOPERATIVE COGNITIVE DYSFUNCTION

Intervention Type BEHAVIORAL

NEURON SPECIFIC ENOLASE LEVELS IN LUMBAR DISC HERNIECTOMY WITH GENERAL ANESTHESIA MODALITIES

Interventions

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POSTOPERATIVE COGNITIVE DYSFUNCTION

NEURON SPECIFIC ENOLASE LEVELS IN LUMBAR DISC HERNIECTOMY WITH GENERAL ANESTHESIA MODALITIES

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

-Lumbal disc herniectomy operation 18-65 age

Exclusion Criteria

* Patients before and after the coronary artery bypass graft surgery
* patients in the last trimester of pregnancy
* patients with severe heart failure
* liver failure
* kidney failure
* malignant hyperthermia
* lactating patients
* patients with vision or hearing problems
* patients having difficulty in understanding and speaking Turkish
* Parkinson's and Alzheimer's disease
* alcohol and drug addicts
* morbidly obese patients
* intraoperative hypotension, hypertension and hypoxemia
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Erzincan University

OTHER

Sponsor Role lead

Responsible Party

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TULAY CEREN OLMEZTURK KARAKURT

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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TÜLAY CEREN ÖLMEZTÜRK KARAKURT

Role: PRINCIPAL_INVESTIGATOR

ERZINCAN BYU

Locations

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Erzincan Byu

Erzincan, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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UFUK KUYRUKLUYILDIZ

Role: CONTACT

05325840554

Facility Contacts

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TÜLAY CEREN ÖLMEZTÜRK KARAKURT

Role: primary

05058616006

References

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Goswami U, Babbar S, Tiwari S. Comparative evaluation of the effects of propofol and sevoflurane on cognitive function and memory in patients undergoing laparoscopic cholecystectomy: A randomised prospective study. Indian J Anaesth. 2015 Mar;59(3):150-5. doi: 10.4103/0019-5049.153036.

Reference Type RESULT
PMID: 25838586 (View on PubMed)

Luescher T, Mueller J, Isenschmid C, Kalt J, Rasiah R, Tondorf T, Gamp M, Becker C, Sutter R, Tisljar K, Schuetz P, Marsch S, Hunziker S. Neuron-specific enolase (NSE) improves clinical risk scores for prediction of neurological outcome and death in cardiac arrest patients: Results from a prospective trial. Resuscitation. 2019 Sep;142:50-60. doi: 10.1016/j.resuscitation.2019.07.003. Epub 2019 Jul 12.

Reference Type RESULT
PMID: 31306716 (View on PubMed)

Baysalman HB, Oğuz G, Açıkgöz G, Aksakal FN, Ünver SJJotTA, Dergisi ICS-JTAvR. Total İntravenöz ve Desfluran Anestezilerinin Erken Derlenme ve Kognitif Fonksiyonlara Etkileri. 2011;39(1).

Reference Type RESULT

Other Identifiers

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19/10

Identifier Type: -

Identifier Source: org_study_id

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