Effect of Low Flow Anesthetics on Neurocognitive Decline in the Elderly
NCT ID: NCT05548998
Last Updated: 2022-09-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
230 participants
OBSERVATIONAL
2019-05-01
2019-11-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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High flow cohort (HFA)
Patients, whose maintenance phase of anesthesia is managed with a fresh gas flow ≥ 1L/min, were included in this cohort.
General anesthesia with high fresh gas flow
General anesthesia with a fresh gas flow equal to or higher than 1L/min for the maintenance phase of anesthesia
Mini mental state examination
6 category and 30-point test to inquire patient's cognitive function
Visual Analogue Scale
The patient's self-reported pain intensity according to a visual scale between 0 and 100
Low flow cohort (LFA)
Patients, whose maintenance phase of anesthesia is managed with a fresh gas flow \< 1L/min, were included in this cohort.
General anesthesia with low fresh gas flow
General anesthesia with a fresh gas flow lower than 1L/min for the maintenance phase of anesthesia
Mini mental state examination
6 category and 30-point test to inquire patient's cognitive function
Visual Analogue Scale
The patient's self-reported pain intensity according to a visual scale between 0 and 100
Interventions
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General anesthesia with low fresh gas flow
General anesthesia with a fresh gas flow lower than 1L/min for the maintenance phase of anesthesia
General anesthesia with high fresh gas flow
General anesthesia with a fresh gas flow equal to or higher than 1L/min for the maintenance phase of anesthesia
Mini mental state examination
6 category and 30-point test to inquire patient's cognitive function
Visual Analogue Scale
The patient's self-reported pain intensity according to a visual scale between 0 and 100
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Consenting to participate
* Scheduled for surgery longer than 2 hours under GA
* Able to read and write
Exclusion Criteria
* Refusing to participate
* Existing visual impairment preventing the patient from reading or writing
* Unable to read and write
* Existing major neurocognitive disorder
* Use of TIVA or regional techniques
* Allergies to the volatile agents
* Uncontrolled DM, acute alcohol intoxication
* Conditions increasing tissue oxygen consumption (sepsis, thyrotoxicosis, etc.)
* Anticipation/existence of major hemorrhage
* Haemodynamic instability \> 10 min or more than 5 times intraoperatively
65 Years
ALL
No
Sponsors
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Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
OTHER
Responsible Party
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Namigar Turgut
Professor
Principal Investigators
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Namigar TURGUT
Role: PRINCIPAL_INVESTIGATOR
Prof. Dr. Cemil Taşcıoğlu City Hospital
Locations
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Prof. Dr. Cemil Taşcıoğlu City Hospital
Istanbul, , Turkey (Türkiye)
Countries
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Other Identifiers
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1206
Identifier Type: -
Identifier Source: org_study_id
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