Acute Exercise Responses With Blood Flow Restriction Under Dynamic Pressure Compared to Fixed Pressure in Patients With Severe Gonarthrosis
NCT ID: NCT07316933
Last Updated: 2026-01-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
45 participants
INTERVENTIONAL
2026-01-31
2026-12-31
Brief Summary
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Each participant will complete six individual sessions under different training conditions, assigned in a random order with a 72-hour interval between each session.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Low-load resistance exercise with moderate blood occlusion and dynamic pressure.
A single session of exercise, 30% repetition maximum, 50% blood occlusion, and dynamic pressure
Moderate-intensity resistance exercise with low arterial occlusion pressure and dynamic pressure.
A single quadriceps extension exercise at 50% of 1RM with dynamic occlusion at 30% of limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Low-load resistance exercise with moderate blood occlusion and fixed pressure.
A single session of exercise, 30% repetition maximum, 50% blood occlusion, and fixed pressure
Moderate-intensity resistance exercise with low arterial occlusion pressure and fixed pressure.
A single quadriceps extension exercise at 50% of 1RM with a fixed occlusion of 30% of the limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Moderate-load resistance exercise with low blood occlusion and dynamic pressure.
A single session of exercise, 50% repetition maximum, 30% blood occlusion, and dynamic pressure
Low-intensity resistance exercise with high arterial occlusion pressure and dynamic pressure.
A single quadriceps extension exercise at 15% of 1RM with a dynamic occlusion of 80% of the limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Moderate-load resistance exercise with low blood occlusion and fixed pressure.
A single session of exercise, 50% repetition maximum, 30% blood occlusion, and fixed pressure
Low-intensity resistance exercise with high arterial occlusion pressure and fixed pressure.
A single quadriceps extension exercise at 15% of 1RM with a fixed occlusion of 80% of the limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Low-load resistance exercise with high blood occlusion and dynamic pressure
A single session of exercise, 15% repetition maximum, 80% blood occlusion, and dynamic pressure
Low-intensity resistance exercise with moderate arterial occlusion pressure and dynamic pressure.
A single quadriceps extension exercise at 30% of 1 repetition maximum (1RM) with dynamic occlusion at 50% of limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Low-load resistance exercise with high blood occlusion and fixed pressure
A single session of exercise, 15% repetition maximum, 80% blood occlusion, and fixed pressure
Low-intensity resistance exercise with moderate arterial occlusion pressure and fixed pressure.
A single quadriceps extension exercise at 30% of 1RM with fixed occlusion at 50% of limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Interventions
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Low-intensity resistance exercise with moderate arterial occlusion pressure and dynamic pressure.
A single quadriceps extension exercise at 30% of 1 repetition maximum (1RM) with dynamic occlusion at 50% of limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Low-intensity resistance exercise with moderate arterial occlusion pressure and fixed pressure.
A single quadriceps extension exercise at 30% of 1RM with fixed occlusion at 50% of limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Moderate-intensity resistance exercise with low arterial occlusion pressure and dynamic pressure.
A single quadriceps extension exercise at 50% of 1RM with dynamic occlusion at 30% of limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Moderate-intensity resistance exercise with low arterial occlusion pressure and fixed pressure.
A single quadriceps extension exercise at 50% of 1RM with a fixed occlusion of 30% of the limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Low-intensity resistance exercise with high arterial occlusion pressure and dynamic pressure.
A single quadriceps extension exercise at 15% of 1RM with a dynamic occlusion of 80% of the limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Low-intensity resistance exercise with high arterial occlusion pressure and fixed pressure.
A single quadriceps extension exercise at 15% of 1RM with a fixed occlusion of 80% of the limb occlusion pressure (LOP), performing 4 sets of 30, 15, 15, 15 repetitions with 30 seconds of rest between sets.
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of severe gonarthrosis according to the clinical and radiographic criteria of the American College of Rheumatology guidelines.
* On the waiting list for unilateral total knee replacement (TKR) surgery
Exclusion Criteria
* Previous hip or knee replacement surgery and osteotomy within the last year.
* Autoimmune arthritis
* Medical conditions that contraindicate exercise.
* Participation in exercise programs (\>2 days/week with training at intensities of 10-15 1RM) in the previous six months.
* History of stroke, brain surgery, major depression, or self-reported cognitive impairment that could affect performance in the study.
* Cardiovascular, thrombotic, or vascular risk factors (uncontrolled hypertension, peripheral arterial disease, history of deep vein thrombosis or pulmonary embolism, heart failure, severe varicose veins, or uncontrolled anticoagulant therapy).
* Skin or local alterations at the cuff application site (ulcers, open wounds, infections, lymphedema, or severe edema).
* Inability to communicate normally or with impaired communication skills.
50 Years
85 Years
ALL
No
Sponsors
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University of Valencia
OTHER
Responsible Party
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Adrián Escriche Escuder
Assistant professor
Locations
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University of Valencia
Valencia, Valencia, Spain
Countries
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Central Contacts
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Other Identifiers
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2025-FIS-3955989
Identifier Type: -
Identifier Source: org_study_id
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