Resistance Exercise and Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover
NCT ID: NCT01245283
Last Updated: 2014-12-05
Study Results
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View full resultsBasic Information
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COMPLETED
NA
90 participants
INTERVENTIONAL
2010-11-30
2013-06-30
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Wait-list Non-exercise Control (CON)
Subjects will continue to participate in their normal activities and clinical care during the four month study period if assigned to this group.
normal activities and clinical care
Subjects will continue to participate in their normal activities and clinical care during the four month study. Telephone contact will be made weekly to encourage adherence to the knee management guidelines
Concentric Focused RX (CRX)
Training protocol for 1 set of each exercise will be completed - leg press, leg curl, leg extension, chest press, seated row, overhead press, triceps dip, biceps curl, and calf press.
Concentric Focused Resistance Exercise
Two resistance exercise sessions per week; 1 set of 10-12 repetitions of each exercise will be completed - leg press, leg curl, leg extension, chest press, seated row, overhead press, triceps dip, biceps curl, and calf press.
Eccentric Focused RX (ERX)
The Human Dynamics Laboratory features prototype equipment that increases resistance loads during the eccentric phase of the contraction while "assistance" is provided by the machine during the concentric phase. One set of each exercise - leg press, leg curl, leg extension, chest press, seated row, overhead press, triceps dip, biceps curl, and calf press.
Eccentric Focused Resistance Exercise
Two resistance exercise sessions per week; 1 set of 10-12 repetitions of each exercise will be completed - leg press, leg curl, leg extension, chest press, seated row, overhead press, triceps dip, biceps curl, and calf press.
Interventions
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normal activities and clinical care
Subjects will continue to participate in their normal activities and clinical care during the four month study. Telephone contact will be made weekly to encourage adherence to the knee management guidelines
Concentric Focused Resistance Exercise
Two resistance exercise sessions per week; 1 set of 10-12 repetitions of each exercise will be completed - leg press, leg curl, leg extension, chest press, seated row, overhead press, triceps dip, biceps curl, and calf press.
Eccentric Focused Resistance Exercise
Two resistance exercise sessions per week; 1 set of 10-12 repetitions of each exercise will be completed - leg press, leg curl, leg extension, chest press, seated row, overhead press, triceps dip, biceps curl, and calf press.
Eligibility Criteria
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Inclusion Criteria
* moderate to severe pain immediately following a 50-foot walk
* knee pain primarily due to tibiofemoral OA and not from patellofemoral OA
* bilateral standing anterior-posterior radiograph demonstrating grade 2 or 3 OA of the target knee
* willing and able to participate in regular exercise for four months
* free from musculoskeletal limitations that would preclude resistance exercise participation
* free of abnormal cardiovascular responses during the screening graded maximal walk test
Exclusion Criteria
* regular resistance exercise training (\>3X week) within the past 6 months
* specific low back pain or acute back injury
* spinal stenosis that precludes walking one block due to neurogenic claudication
* any major injury to either knee within the prior 12 months
* any surgery to either knee within the last 12 months
* lumbar radiculopathy
* vascular claudication
* significant anterior knee pain due to diagnosed isolated patella-femoral syndrome or chondromalacia in either knee
* have had corticosteroid or viscosupplement injections within three months of study participation
* have added new over the counter or prescription pain medication within two months of study participation
60 Years
85 Years
ALL
No
Sponsors
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University of Florida
OTHER
Responsible Party
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Principal Investigators
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Kevin R Vincent, M.D. Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of Florida Department of Orthopaedics and Rehabilitaion
Locations
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UF&Shands Orthopaedics and Sports Medicine Institute
Gainesville, Florida, United States
Countries
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Other Identifiers
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614-2009
Identifier Type: -
Identifier Source: org_study_id