Exercise Therapy in Combination With Central Nervous System-targeted Treatment for Osteoarthritis

NCT ID: NCT03681613

Last Updated: 2024-07-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

121 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-07

Study Completion Date

2022-08-30

Brief Summary

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The aim of this study is to investigate if exercise therapy comprising the NEMEX program in combination with a CNS-targeted treatment using GMI and SDT is superior to exercise therapy alone in improving self-reported pain, function, quality of life and objective measures related to hyperexcitability of the CNS (e.g. central sensitization) in people with KOA.

Detailed Description

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Participants will be randomized to one of two treatments initiated after randomization: the NEMEX program combined with a CNS-focused protocol or the NEMEX program alone.

The NEMEX program will consist of 12-weeks of individualized and supervised exercise sessions applied twice weekly (n=24 sessions). Each exercise session will last approximately 60minutes and include three parts: warming up, a circuit program and cooling down.

The CNS-targeted treatment will consist of 12-week individualized and supervised sessions applied twice weekly. Each training session will last approximately 30 minutes and include three parts, which are further explained below: 1) discussion of the participant's knee pain experience from a pain neuroscience perspective, 2) graded SDT and 3) GMI training.

Conditions

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Osteoarthritis Osteo Arthritis Knee

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Exercise Therapy With CNS Treatment

NEMEX program combined with a CNS-focused protocol

Group Type EXPERIMENTAL

NEMEX program combined with a CNS-focused protocol

Intervention Type OTHER

The NEMEX program will consist of 12-weeks of individualized and supervised exercise sessions applied twice weekly (n=24 sessions). Each exercise session will last approximately 60minutes and include three parts: warming up, a circuit program and cooling down.

The CNS-targeted treatment will consist of 12-week individualized and supervised sessions applied once weekly. Each training session will last approximately 30 minutes and include three parts, which are further explained below: 1) discussion of the participant's knee pain experience from a pain neuroscience perspective, 2) graded SDT and 3) GMI training.

Exercise Therapy alone

NEMEX program alone

Group Type EXPERIMENTAL

NEMEX program

Intervention Type OTHER

The NEMEX program will consist of 12-weeks of individualized and supervised exercise sessions applied twice weekly (n=24 sessions). Each exercise session will last approximately 60minutes and include three parts: warming up, a circuit program and cooling down.

Interventions

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NEMEX program combined with a CNS-focused protocol

The NEMEX program will consist of 12-weeks of individualized and supervised exercise sessions applied twice weekly (n=24 sessions). Each exercise session will last approximately 60minutes and include three parts: warming up, a circuit program and cooling down.

The CNS-targeted treatment will consist of 12-week individualized and supervised sessions applied once weekly. Each training session will last approximately 30 minutes and include three parts, which are further explained below: 1) discussion of the participant's knee pain experience from a pain neuroscience perspective, 2) graded SDT and 3) GMI training.

Intervention Type OTHER

NEMEX program

The NEMEX program will consist of 12-weeks of individualized and supervised exercise sessions applied twice weekly (n=24 sessions). Each exercise session will last approximately 60minutes and include three parts: warming up, a circuit program and cooling down.

Intervention Type OTHER

Other Intervention Names

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Graded Motor Imagery Sensory Discrimination Training NEMEX program

Eligibility Criteria

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Inclusion Criteria

* Patients with symptomatic and radiographically-confirmed tibiofemoral KOA (e.g. Kellgren-Lawrence ≥2, scored by an orthopaedic surgeon, not scheduled for total knee replacement \[decision among other factors based on pain, function and radiographic severity.
* Diagnosis of KOA according to the EULAR classification criteria: adults aged \>40 years with usage-related knee pain, only short-lived (\<30min) morning stiffness, functional limitation (based on yes/no to the following question: Is your functional level reduced as compared to before your knee symptoms first started?) and one or more typical examination findings (crepitus, restricted movement, bony enlargement). The presence of this cluster correctly diagnosed 99% of cases with KOA.

Exclusion Criteria

* Less than mild functional limitations (a score above 75 on a 0-100 worst to best scale in the Spanish version of the self-report questionnaire Knee injury and Osteoarthritis Outcome Score (KOOS)4 defined as the average score for the subscale scores for pain, symptoms, activities of daily living (ADL) and quality of life (QOL).
* Previous knee replacement or any other lower limb surgery in the affected knee within the previous 3 months.
* Fracture of the affected extremity within the previous 6 months.
* Initiation of opioid analgesia or any form of injection (i.e. corticosteroid, hyaluronic acid, platelet-rich plasma) for knee pain within the previous 30 days.
* Physical impairments unrelated to the knee that would prevent safe participation in exercise.
* Any comorbidity that prevents from participating in the interventions (e.g.uncontrolled hypertension, moderate to high risk for cardiac complications)
* Any skin or medical condition preventing tactile stimulation on the knee.
* Inability to comprehend and complete study assessments or comply with study instructions (e.g. illiteracy, cognitive or visual impairments).
* Inability to a priori attend or complete the proposed course of intervention and follow-up schedule.
Minimum Eligible Age

41 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Valencia

OTHER

Sponsor Role lead

Responsible Party

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Enrique Lluch Girbés

PhD Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Enrique Lluch Girbés, PhD

Role: STUDY_DIRECTOR

University of Valencia

Søren Thorgaard Skou, PhD

Role: STUDY_CHAIR

University of Southern Denmark

Javier Peral Pérez, PhD student

Role: PRINCIPAL_INVESTIGATOR

University of Alcalá

Locations

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University of Valencia

Valencia, , Spain

Site Status

Countries

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Spain

References

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Other Identifiers

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H1526892955402

Identifier Type: -

Identifier Source: org_study_id

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