Caffeine Dose: Performance and Recovery

NCT ID: NCT07090421

Last Updated: 2025-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-07-24

Study Completion Date

2022-08-24

Brief Summary

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The goal of this clinical trial is to learn how different doses of caffeine taken in the evening affect rowing performance, sleep quality, and daytime alertness in trained male university rowers. The main questions it aims to answer are:

Does a low, moderate, or high caffeine dose improve rowing performance? How do these doses affect sleep and recovery after evening exercise? Participants completed four rowing tests after consuming either a placebo, low (3 mg/kg), moderate (6 mg/kg), or high (9 mg/kg) dose of caffeine. Researchers measured rowing time, power, heart rate, sleep quality, and daytime sleepiness.

The study found that moderate and high caffeine doses improved rowing performance the most. However, these same doses made it harder for participants to sleep well and feel alert the next day. Headaches and stomach issues were also more common with the high dose. The low dose gave smaller performance gains but caused fewer side effects.

This study shows that evening caffeine can boost performance but may hurt recovery and sleep. Athletes and coaches should weigh these trade-offs when using caffeine for late-day training or competition.

Detailed Description

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This double-blind, randomized crossover study examined the dose-dependent effects of evening caffeine ingestion on rowing performance, sleep quality, and daytime alertness in trained male university rowers. The rationale stems from increasing use of caffeine as a performance-enhancing supplement in evening training or competition settings, despite its known adverse effects on sleep and recovery. Thirteen participants completed four experimental trials (placebo, 3 mg/kg, 6 mg/kg, 9 mg/kg caffeine), each separated by a washout period, during which they performed a 2000-meter rowing time trial and were assessed for sleep quality and daytime sleepiness using validated scales. The study also recorded physiological responses and adverse events across conditions. By evaluating multiple doses, the design allowed for assessment of both efficacy and tolerability thresholds, supporting dose-optimization strategies. This study aims to inform practical guidelines for athletes and coaches balancing acute ergogenic benefits with potential recovery trade-offs when caffeine is used late in the day.

Conditions

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Healthy Volunteers Caffeine Sleep Quality

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

Participants ingested an inert cellulose capsule containing no active substance approximately 60 minutes prior to performing a 2000-meter rowing ergometer time trial. This condition served as the control to compare the effects of caffeine ingestion at varying doses.

Group Type PLACEBO_COMPARATOR

Cellulose Powder

Intervention Type DIETARY_SUPPLEMENT

Participants consumed an inert cellulose powder dissolved in water, containing no active caffeine. The placebo was ingested orally 60 minutes prior to the rowing performance test. This condition served as the control and was administered once per session in a randomized, double-blind, crossover design.

Low Dose Caffeine

Participants ingested a caffeine capsule at a dosage of 3 mg per kg of body mass approximately 60 minutes before the 2000-meter rowing ergometer trial. This condition was included to evaluate the ergogenic and sleep-related effects of a low evening caffeine dose.

Group Type EXPERIMENTAL

Caffeine 3 mg/kg Oral Powder

Intervention Type DIETARY_SUPPLEMENT

Participants consumed caffeine in powder form at a dose of 3 milligrams per kilogram of body weight. The powder was dissolved in water and ingested orally approximately 60 minutes before the start of the 2000-meter rowing ergometer performance test. The intervention was administered once per session in a randomized, double-blind, crossover design.

Moderate Dose Caffeine

Participants ingested a caffeine capsule at a dosage of 6 mg per kg of body mass approximately 60 minutes before performing the 2000-meter rowing ergometer test. This condition represented a commonly used moderate dose to examine its impact on performance and sleep parameters.

Group Type EXPERIMENTAL

Caffeine 6 mg/kg Oral Powder

Intervention Type DIETARY_SUPPLEMENT

Participants ingested caffeine in powder form, dissolved in water, at a dose of 6 milligrams per kilogram of body mass. The solution was consumed orally 60 minutes prior to the 2000-meter rowing performance test. This intervention was administered once per session as part of a randomized, double-blind, crossover design.

High Dose Caffeine

Participants ingested a caffeine capsule at a dosage of 9 mg per kg of body mass approximately 60 minutes prior to the rowing trial. This high-dose condition was used to assess the maximum ergogenic potential of caffeine and its possible detrimental effects on sleep quality and next-day recovery.

Group Type EXPERIMENTAL

Caffeine 9 mg/kg Oral Powder

Intervention Type DIETARY_SUPPLEMENT

A powdered caffeine dose of 9 milligrams per kilogram was dissolved in water and consumed orally by participants 60 minutes before a 2000-meter rowing ergometer trial. The intervention was administered once per session under a randomized, double-blind, crossover design.

Interventions

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Cellulose Powder

Participants consumed an inert cellulose powder dissolved in water, containing no active caffeine. The placebo was ingested orally 60 minutes prior to the rowing performance test. This condition served as the control and was administered once per session in a randomized, double-blind, crossover design.

Intervention Type DIETARY_SUPPLEMENT

Caffeine 3 mg/kg Oral Powder

Participants consumed caffeine in powder form at a dose of 3 milligrams per kilogram of body weight. The powder was dissolved in water and ingested orally approximately 60 minutes before the start of the 2000-meter rowing ergometer performance test. The intervention was administered once per session in a randomized, double-blind, crossover design.

Intervention Type DIETARY_SUPPLEMENT

Caffeine 6 mg/kg Oral Powder

Participants ingested caffeine in powder form, dissolved in water, at a dose of 6 milligrams per kilogram of body mass. The solution was consumed orally 60 minutes prior to the 2000-meter rowing performance test. This intervention was administered once per session as part of a randomized, double-blind, crossover design.

Intervention Type DIETARY_SUPPLEMENT

Caffeine 9 mg/kg Oral Powder

A powdered caffeine dose of 9 milligrams per kilogram was dissolved in water and consumed orally by participants 60 minutes before a 2000-meter rowing ergometer trial. The intervention was administered once per session under a randomized, double-blind, crossover design.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Male university-level rowers
* Aged approximately 22 ± 2.2 years
* Minimum of 2 years of rowing training experience
* Free of any medical condition that impairs exercise participation
* Regular caffeine consumers (habitual daily intake recorded)
* Voluntarily signed informed consent form
* Available to attend all scheduled laboratory sessions

Exclusion Criteria

* Any medical condition that could interfere with study participation or protocol adherence
* Use of prescription medications during the study period
* Known allergy to mannitol or other artificial sweeteners
* Diagnosed sleep disorders (e.g., insomnia, sleep apnea)
* Physician's advice to limit or avoid caffeine intake
Minimum Eligible Age

20 Years

Maximum Eligible Age

25 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Ulaç Can YILDIRIM

OTHER

Sponsor Role lead

Responsible Party

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Ulaç Can YILDIRIM

Assoc. Prof.

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Ulas C. Yildirim, pHd

Role: PRINCIPAL_INVESTIGATOR

Sinop University

Locations

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Sinop University Facility

Sinop, Centarl, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Ali A, O'Donnell JM, Starck C, Rutherfurd-Markwick KJ. The Effect of Caffeine Ingestion during Evening Exercise on Subsequent Sleep Quality in Females. Int J Sports Med. 2015 Jun;36(6):433-9. doi: 10.1055/s-0034-1398580. Epub 2015 Feb 20.

Reference Type BACKGROUND
PMID: 25700100 (View on PubMed)

Anderson ME, Bruce CR, Fraser SF, Stepto NK, Klein R, Hopkins WG, Hawley JA. Improved 2000-meter rowing performance in competitive oarswomen after caffeine ingestion. Int J Sport Nutr Exerc Metab. 2000 Dec;10(4):464-75. doi: 10.1123/ijsnem.10.4.464.

Reference Type BACKGROUND
PMID: 11099373 (View on PubMed)

Bonnar D, Bartel K, Kakoschke N, Lang C. Sleep Interventions Designed to Improve Athletic Performance and Recovery: A Systematic Review of Current Approaches. Sports Med. 2018 Mar;48(3):683-703. doi: 10.1007/s40279-017-0832-x.

Reference Type BACKGROUND
PMID: 29352373 (View on PubMed)

Chen B, Ding L, Qin Q, Lei TH, Girard O, Cao Y. Effect of caffeine ingestion on time trial performance in cyclists: a systematic review and meta-analysis. J Int Soc Sports Nutr. 2024 Dec;21(1):2363789. doi: 10.1080/15502783.2024.2363789. Epub 2024 Jun 5.

Reference Type BACKGROUND
PMID: 38836626 (View on PubMed)

de Souza JG, Del Coso J, Fonseca FS, Silva BVC, de Souza DB, da Silva Gianoni RL, Filip-Stachnik A, Serrao JC, Claudino JG. Risk or benefit? Side effects of caffeine supplementation in sport: a systematic review. Eur J Nutr. 2022 Dec;61(8):3823-3834. doi: 10.1007/s00394-022-02874-3. Epub 2022 Apr 5.

Reference Type BACKGROUND
PMID: 35380245 (View on PubMed)

Drapeau C, Hamel-Hebert I, Robillard R, Selmaoui B, Filipini D, Carrier J. Challenging sleep in aging: the effects of 200 mg of caffeine during the evening in young and middle-aged moderate caffeine consumers. J Sleep Res. 2006 Jun;15(2):133-41. doi: 10.1111/j.1365-2869.2006.00518.x.

Reference Type BACKGROUND
PMID: 16704567 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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2021/80

Identifier Type: -

Identifier Source: org_study_id

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