Caffeine Supplementation, Resistance Training and Blood Antioxidant Status

NCT ID: NCT05230303

Last Updated: 2023-03-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 15 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-01-12
• Study Completion Date: 2023-01-31

Brief Summary

The purpose of this study is to verify the effect of acute caffeine intake on resistance training volume and blood antioxidant status, in a randomised, double-blind, placebo-controlled crossover trial.

Detailed Description

Caffeine is one of the most commonly consumed psychoactive substances in the world. Several previous studies confirmed that caffeine improves several aspects of exercise performance, including resistance training outcomes. Interestingly, caffeine and its catabolic products, theobromine and xanthine, exhibit antioxidant and prooxidant properties. Additionally, resistance training promotes the generation of reactive oxygen species, which are important for the cellular adaptation process.

Hovewer, to the best of our knowledge, there is no information as to how caffeine combined with resistance training affects blood antioxidant status. Therefore, the aim of this study was to examine acute effects of caffeine supplementation on resistance training volume and blood antioxidant status in resistance trained men.

Conditions

Caffeine

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Caffeine supplementation

Group taking 3 mg/kg of caffeine

Group Type: EXPERIMENTAL

Caffeine supplementation

Intervention Type: DIETARY_SUPPLEMENT

Two identical experimental sessions with a one-week interval between sessions (to allow complete recovery and ensure substance wash-out) will be taken. During the experimental sessions, participants will ingest caffeine in dose of 3 mg/kg of body mass. Caffeine will be provided in capsules containing the individual amount of caffeine and will be administered orally 60 min before the onset of the exercise protocol.

Placebo treatment

Group taking placebo

Group Type: PLACEBO_COMPARATOR

Placebo treatment

Intervention Type: DIETARY_SUPPLEMENT

The experimental procedure for each particpant will include placebo supplementation. The manufacturer of the caffeine capsules will also prepare identical placebo capsules filled out with a microcrystalline cellulose. Placebo will be administered orally 60 min before the onset of the exercise protocol.

Interventions

Caffeine supplementation

Two identical experimental sessions with a one-week interval between sessions (to allow complete recovery and ensure substance wash-out) will be taken. During the experimental sessions, participants will ingest caffeine in dose of 3 mg/kg of body mass. Caffeine will be provided in capsules containing the individual amount of caffeine and will be administered orally 60 min before the onset of the exercise protocol.

Intervention Type: DIETARY_SUPPLEMENT

Placebo treatment

The experimental procedure for each particpant will include placebo supplementation. The manufacturer of the caffeine capsules will also prepare identical placebo capsules filled out with a microcrystalline cellulose. Placebo will be administered orally 60 min before the onset of the exercise protocol.

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• written consent to participate,
• medical permission by physician
• "resistance-trained," defined as having a minimum of two years of resistance training experience
• minimum of 2 workout sessions per week in the last 6 months

Exclusion Criteria

• neuromuscular or musculoskeletal disorders
• current injury
• using any medications, dietary supplements or ergogenic aids which could potentially affect the study outcomes
• a positive smoking status
• potential allergy to caffeine

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

The Jerzy Kukuczka Academy of Physical Education in Katowice

OTHER

Sponsor Role: lead

Responsible Party

Aleksandra Filip-Stachnik

PhD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Adam Zając, Profesor

Role: STUDY_DIRECTOR

The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland

Locations

The Jerzy Kukuczka Academy of Physical Education

Katowice, , Poland

Countries

Poland

References

Filip-Stachnik A, Krzysztofik M, Del Coso J, Palka T, Sadowska-Krepa E. The Effect of Acute Caffeine Intake on Resistance Training Volume, Prooxidant-Antioxidant Balance and Muscle Damage Markers Following a Session of Full-Body Resistance Exercise in Resistance-Trained Men Habituated to Caffeine. J Sports Sci Med. 2023 Sep 1;22(3):436-446. doi: 10.52082/jssm.2023.436. eCollection 2023 Sep.

Reference Type: DERIVED

PMID: 37711718 (View on PubMed)

Other Identifiers

01_2021

Identifier Type: -

Identifier Source: org_study_id