Triglyceride-Glucose Indices and Left Ventricular Speckle Tracking in Predicting Coronary Artery Disease Severity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

508 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-04-30

Study Completion Date

2025-07-03

Brief Summary

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Our study specifically will address the value of modified triglyceride glucose indices versus left ventricular speckle tracking in prediction of severity of coronary artery disease assessed by Gensini score.

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Detailed Description

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A cross sectional study that will be conducted in Cardiovascular Department of Tanta University in Egypt in the period from May to July 2025 . Two hundred patients diagnosed with coronary artery diseases were included in the study. Patients were considered to have confirmed coronary artery disease through angiographically proven CAD.

Provision of privacy:

Privacy of all data is guaranteed and there will be a code number for every patient and include all of his or her investigations.

Informed consent:

Informed written consent will be obtained from all patients after full explanation of benefits and risks of the study.

Methods: Study patients and procedures:

Selection criteria included any patient with chronic stable angina and proved coronary artery disease by coronary angiography Exclusion criteria included: Any patients with acute coronary syndrome, arrhythmias, previous Percutaneous coronary intervention (PCI) or Coronary Artery Bypass Graft (CABG) surgery

All the participants were subjected to following:

1. History taking for presence of risk factors of cardio vascular disease as age, sex, smoking, physical inactivity, diabetes and hypertension.
2. Physical examination including height, weight and waste circumference
3. Resing 12 leads ECG
4. Laboratory investigations:

* Fasting blood glucose (FBG)
* Triglyceride (TG), TG index.
* Total Cholesterol level
* Renal Function test . Echocardiographic evaluation

6\. Coronary angiography 7. Gensini score calculated by summation of the individual coronary segment scores.

Conditions

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Coronary Artery Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Interventions

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TyG-derived index.

Derived indices included:

* Ty,G×B,M,I = TyG index × body mass index
* TyG×W,C = TyG index × waist circumference
* TyG×WH,tR = TyG index × waist-to-height ratio Quartile-based stratification was applied to each TyG-derived index.

Intervention Type DIAGNOSTIC_TEST

Left Ventricular Speckle Tracking

Coronary Angiography and Gensini Scoring: All participants underwent standard diagnostic coronary angiography. CAD was categorized as one-, two-, or three-vessel disease based on the number of vessels with ≥50% stenosis. The severity of CAD was quantified using the Gensini score, which assigns a severity weight to each lesion depending on degree of stenosis and anatomical location. Final scores were calculated by summing weighted values across all coronary segments.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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TG index Echocardiographic Assessment

Eligibility Criteria

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Inclusion Criteria

* diagnosis of CAD with ≥50% stenosis in at least one major coronary artery.

Exclusion Criteria

* Patients with acute coronary syndrome, arrhythmias, previous coronary interventions (PCI or CABG), or inability to undergo echocardiographic assessment.

Minimum Eligible Age

38 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No