Triglycerides Glucose Index on Angiographic Profiling of Non-Diabetic Premature Coronary Artery Disease Patients
NCT ID: NCT07154186
Last Updated: 2025-09-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
180 participants
OBSERVATIONAL
2025-09-04
2026-02-01
Brief Summary
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Detailed Description
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Insulin resistance and associated metabolic alterations are strongly implicated in premature atherosclerosis. Even in non-diabetic individuals, subclinical insulin resistance promotes endothelial dysfunction, oxidative stress, and low-grade inflammation, leading to early vascular damage.
The triglyceride-glucose (TyG) index, calculated using fasting glucose and triglyceride levels, has emerged as a cost-effective surrogate marker for insulin resistance.
Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Group L
Patients with a low triglyceride-glucose (TyG) index tertile.
Coronary Angiographic Assessment
Coronary angiographic assessment will be performed for all patients.
Group H
Patients with a high triglyceride-glucose (TyG) index tertile.
Coronary Angiographic Assessment
Coronary angiographic assessment will be performed for all patients.
Interventions
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Coronary Angiographic Assessment
Coronary angiographic assessment will be performed for all patients.
Eligibility Criteria
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Inclusion Criteria
* Both sexes.
* Non-diabetic patients \[no history of diabetes, hemoglobin A1C (HbA1C) \< 6.5%, fasting glucose \< 126 mg/dL\].
* Confirmed diagnosis of coronary artery disease (CAD) by coronary angiography.
Exclusion Criteria
* Previous history of coronary revascularization.
* Severe hepatic or renal dysfunction \[alanine transaminase (ALT)/aspartate aminotransferase (AST) ≥ 5× upper limit of normal (ULN), estimated glomerular filtration rate (eGFR)\< 30 mL/min/1.73 m²\].
* Malignant disease, autoimmune disease, or systemic inflammatory disorders.
* Current use of triglyceride-lowering medications.
18 Years
ALL
No
Sponsors
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Sohag University
OTHER
Responsible Party
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Remon Saleh Adly
Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.
Locations
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Sohag University
Sohag, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Soh-Med-25-5-5PD
Identifier Type: -
Identifier Source: org_study_id
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