Risk Factors for Microvascular Obstruction Post-Emergency PCI in AMI Patients
NCT ID: NCT07042321
Last Updated: 2025-07-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
300 participants
OBSERVATIONAL
2024-06-01
2025-08-31
Brief Summary
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* How does the TyG index correlate with the early detection of MVO?
* What differences in cardiovascular adverse events during hospitalization exist between groups with varying TyG index levels? Participants will undergo emergency PCI and CMR imaging within 3-7 days post-procedure. Data collected will include demographic characteristics, clinical history, coronary angiography data, laboratory test indicators (especially metabolic markers such as blood glucose and lipids), IVUS-related plaque information, and CMR results.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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High TYG Index Group
No interventions assigned to this group
Medium TYG Index Group
No interventions assigned to this group
Low TYG Index Group
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* STEMI symptom onset time \< 12 hours.
* STEMI symptom onset time 12-48 hours, with ongoing ischemic symptoms, hemodynamic instability, or life-threatening ventricular arrhythmias.
* Very high-risk NSTEMI; undergoing emergency PCI treatment.
* Voluntary signed informed consent form.
Exclusion Criteria
* Severe chronic kidney disease (defined as estimated glomerular filtration rate \<20 mL/min per 1.73 m²).
* Pregnant women or those planning to become pregnant.
* Failure of emergency PCI.
* Unclear CMR images
18 Years
ALL
No
Sponsors
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The Third Xiangya Hospital of Central South University
OTHER
Responsible Party
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Yu Cao
Cardiology Professor
Locations
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Xiangya Third Hospital of Central South University
Changsha, Hunan Province,China, China
Countries
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Central Contacts
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Facility Contacts
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References
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Kim MK, Ahn CW, Kang S, Nam JS, Kim KR, Park JS. Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults. Cardiovasc Diabetol. 2017 Aug 23;16(1):108. doi: 10.1186/s12933-017-0589-4.
Soeda T, Higuma T, Abe N, Yamada M, Yokoyama H, Shibutani S, Ong DS, Vergallo R, Minami Y, Lee H, Okumura K, Jang IK. Morphological predictors for no reflow phenomenon after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction caused by plaque rupture. Eur Heart J Cardiovasc Imaging. 2017 Jan;18(1):103-110. doi: 10.1093/ehjci/jev341. Epub 2016 Jan 22.
Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome--a new worldwide definition. Lancet. 2005 Sep 24-30;366(9491):1059-62. doi: 10.1016/S0140-6736(05)67402-8. No abstract available.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Document Type: Informed Consent Form: Informed Consent Form
Document Type: Informed Consent Form: Ethical approval document
Other Identifiers
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cy25231
Identifier Type: -
Identifier Source: org_study_id
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