The Prognosis of Acute Myocardial Infarction

NCT ID: NCT02737956

Last Updated: 2024-03-28

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 7350 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-06-01
• Study Completion Date: 2023-12-10

Brief Summary

This study aims to establish a registry and surveillance system for acute myocardial infarction (AMI) patients in Xinjiang, focusing on collecting comprehensive information including basic patient demographics, patient characteristics, diagnostic methods, treatment programs, and hospitalization outcomes such as mortality, treatment complications, hospitalization costs, and follow-up events (death, major adverse cardiac events). The goal is to identify and propose effective prevention strategies to reduce the incidence of AMI, optimize the management and outcomes of AMI patients by implementing guideline recommendations in clinical practice, and conduct analyses to develop effective treatment strategies and predictive models for clinical outcomes. This focus on Xinjiang aims to provide a comprehensive understanding of AMI within this specific geographic and demographic context, ultimately contributing to improved prevention, treatment, and management of AMI patients.

Detailed Description

The objective of this study is to establish a comprehensive registry and surveillance system for acute myocardial infarction (AMI) patients in Xinjiang. This platform is designed to support clinical research and translational medicine, aiming to improve the quality of AMI patient care through the integration of guideline recommendations into clinical practice. By collecting detailed information on patient demographics, characteristics, diagnostic methods, treatment programs, and outcomes, including mortality, complications, hospitalization costs, and follow-up events such as death and major adverse cardiac events, this study seeks to lay the foundation for future quality improvement initiatives and research. The ultimate goal is to translate research findings into improved care practices for AMI patients, thereby reducing morbidity and mortality associated with the condition. This endeavor will bridge the gap between clinical research and practical healthcare delivery, ensuring that advancements in the treatment and management of AMI directly benefit patients in Xinjiang, contributing to substantial improvements in healthcare outcomes.

Conditions

Acute Myocardial Infarction

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

AMI patients with treatment of PCI

All the patiets treat with PCI were enrolled and recorded the clinical characteristic and outcomes during the follow-up period.

No interventions assigned to this group

Medication

All the patiets treat with medication (standard secondary prevention) without PCI were enrolled and recorded the clinical characteristic and outcomes during the follow-up period.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

Acute myocardial infarction patients in hospitalized of the First Affiliated Hospital of Xinjiang Medical University (include diagnosed acute ST-elevation or non ST-elevation myocardial infarction).Diagnosis criteria must meet Universal Definition for AMI (2012).

Exclusion Criteria

1. Combined with severe valvular heart disease;

2. Combined with severe congenital heart disease;

3. Combined hyperthyroidism, anemia and other high-powered heart disease;

4. With pulmonary heart disease;

5. With hypertrophic obstructive cardiomyopathy;

6. Severe hypotension (SBP <90mmHg or DBP <60mmHg at enrollment);

7. Uncontrolled hypertension (SBP> 160 mmHg before PCI, and / or DBP> 100 mmHg);

8. Liver dysfunction (defined as ALT or total bilirubin is greater than the normal upper limit of 3 times);

9. Renal insufficiency (defined as serum creatinine greater than 1.5 times the normal upper limit);

10. High-risk bleeding patients, such as thrombocytopenia, blood diseases and other diseases;

11. active peptic ulcer and skin ulcers;

12. A patient who is allergic to clopidogrel, tegrellol, or aspirin;

13. Patients with a history of cardiogenic shock within two weeks;

14. pregnant and lactating women, during treatment can not be strict contraception of women of childbearing age;

15. In the past 3 months participated in other clinical researchers;

16. Persons who do not have legal or legal competence;

17. Any condition that the investigator considers unsuitable for participation in the clinical study.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 79 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Xinjiang Medical University

OTHER

Sponsor Role: lead

Responsible Party

Xiang Xie

Xiangxie, MD,Professor, The First Affiliated Hospital Of XinJiang Medicial University

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Xiang Xie, PhD

Role: PRINCIPAL_INVESTIGATOR

Xinjiang Medical University

Locations

First Affilliatted Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, China

Countries

China

References

Yan J, Deng CJ, Wang SF, Aimaitijiang M, Wu TT, Zheng YY, Xie X, Ma YT. Predictive Value of the Modified GRACE Scoring System for All-Cause Mortality in Patients with Acute Myocardial Infarction. Rev Cardiovasc Med. 2023 Jun 6;24(6):161. doi: 10.31083/j.rcm2406161. eCollection 2023 Jun.

Reference Type: DERIVED

PMID: 39077519 (View on PubMed)

Xiu WJ, Yang HT, Zheng YY, Ma YT, Xie X. Delayed PCI 12 Hours after the Onset of Symptoms Is Associated with Improved Outcomes for Patients with ST-Segment Elevation Myocardial Infarction: A Real-World Study. J Interv Cardiol. 2019 Jun 18;2019:2387929. doi: 10.1155/2019/2387929. eCollection 2019.

Reference Type: DERIVED

PMID: 31772517 (View on PubMed)

Other Identifiers

20160317-03

Identifier Type: -

Identifier Source: org_study_id