Incidence Rate of Heart Failure After Acute Myocardial Infarction With Optimal Treatment

NCT ID: NCT03297164

Last Updated: 2021-10-01

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 12043 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-12-21
• Study Completion Date: 2021-06-30

Brief Summary

The main purpose of this study is to build a multi-center, prospective and regionally representative acute myocardial infarction(AMI) cohort，and build a study platform for heart failure caused by AMI; To explore the 1 year incidence rate of heart failure after AMI given the optimized treatment and the treatment model affecting the incidence rate of heart failure, and finally to reduce the incidence rate of heart failure by 5%.

Detailed Description

the study aim to enroll 12000 acute myocardial infartion (AMI) patients, including ST-segment elevation myocardial infarction (STEMI) and non ST-segment elevation myocardial infarction (NSETMI), Patients were divided into two groups(optimized group and un-optimized group) according to treatment models they accepted in 20 reginally representative hosptials of China. whether optimizaed or not is judged by 4 four aspects,including emergency treatment procedure, pre-infusion medication, reperfusion strategy selection, and early rehabilitation after reperfusion.Patients were followed at 1 month, 6 months and 12 months. The physical condition and clinical events(heart failure, death, re-infarction, revascularization, apoplexy, malignant arrhythmias, bleeding events, other adverse events)were collected at follow up.

Conditions

Acute Myocardial Infarction; Heart Failure

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

optimized group

the patients in this group have been given the suggestive treatment from guideline.

No interventions assigned to this group

un-optimized group

the patients in this group have not been given the suggestive treatment from guideline.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• age≥18 years
• diagnosed acute myocardial infarction
• signed the informed consent form

Exclusion Criteria

• AMI is caused by surgery, trauma, gastrointestinal bleeding or complications of PCI;
• AMI occurred in patients who have been hospitalized for other reasons;
• patients with previous history of chronic heart failure;
• researchers judging that patient's compliance was poor and could not complete the study according to the requirements.
• life expectancy is less than 12 months;
• heart transplant patients;
• patients with tumors;

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Harbin Medical University

OTHER

Sponsor Role: lead

Responsible Party

Yu Bo

director

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Beijing An Zhen Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Peking Univerisity People'Hospital

Beijing, Beijing Municipality, China

Beijing Chao-Yang Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Peking University First Hospital

Beijing, Beijing Municipality, China

Guangdong general hospital

Guangzhou, Guangdong, China

The first affiliated hospital of Guangxi medical university

Nanning, Guangxi, China

Second hospital of hebei medical university

Shijiazhuang, Hebei, China

Daqing Oilfield General Hospital

Daqing, Heilongjiang, China

The first affiliated hospital of Zhengzhou medical university

Zhengzhou, Henan, China

Zhongda Hospital Southeast University

Nanjing, Jiangsu, China

The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

The Second Hospital of Jilin University

Changchun, Jilin, China

the second affiliated hospital of Dalian medical university

Dalian, Liaoning, China

Shenyang military district general hospital of the people's liberation army

Shenyang, Liaoning, China

The first affiliated hospital of military medical university

Xi’an, Shanxi, China

Third Military Medical University

Chongqing, Sichuan, China

The General Hospital of Tianjin Medical University

Tianjin, Tianjin Municipality, China

Tianjin Chest Hospital

Tianjin, Tianjin Municipality, China

The First Affiliated Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, China

Countries

China

References

Wang J, Li Z, Yang G, Fang C, Yin Y, Zheng Z, Wang H, Fang S, Dai J, Wang S, Yang S, Yu B. Pseudo-targeted metabolic profile differences between emergency patients with type 1 and type 2 myocardial infarction diagnosed by optical coherence tomography. Clin Chim Acta. 2024 Feb 1;554:117745. doi: 10.1016/j.cca.2023.117745. Epub 2024 Jan 6.

Reference Type: DERIVED

PMID: 38185283 (View on PubMed)

Lang X, Zhao B, Fang S, Li L, Li Z, Wu N, Zhang Y, Xing L, Li Y, Zhang Y. Higher Peripheral Thyroid Sensitivity Is Linked to a Lower Risk of Heart Failure After Acute Myocardial Infarction. J Clin Endocrinol Metab. 2023 Oct 18;108(11):2950-2960. doi: 10.1210/clinem/dgad240.

Reference Type: DERIVED

PMID: 37104944 (View on PubMed)

Zeng M, Zhao C, Bao X, Liu M, He L, Xu Y, Meng W, Qin Y, Weng Z, Yi B, Zhang D, Wang S, Luo X, Lv Y, Chen X, Sun Q, Feng X, Gao Z, Sun Y, Demuyakor A, Li J, Hu S, Guagliumi G, Mintz GS, Jia H, Yu B. Clinical Characteristics and Prognosis of MINOCA Caused by Atherosclerotic and Nonatherosclerotic Mechanisms Assessed by OCT. JACC Cardiovasc Imaging. 2023 Apr;16(4):521-532. doi: 10.1016/j.jcmg.2022.10.023. Epub 2022 Dec 14.

Reference Type: DERIVED

PMID: 36648054 (View on PubMed)

Li L, Zhang X, Wang Y, Yu X, Jia H, Hou J, Li C, Zhang W, Yang W, Liu B, Lu L, Tan N, Yu B, Li K. A Novel Risk Score to Predict In-Hospital Mortality in Patients With Acute Myocardial Infarction: Results From a Prospective Observational Cohort. Front Cardiovasc Med. 2022 Apr 7;9:840485. doi: 10.3389/fcvm.2022.840485. eCollection 2022.

Reference Type: DERIVED

PMID: 35463775 (View on PubMed)

Other Identifiers

2016YFC1301101

Identifier Type: -

Identifier Source: org_study_id