A Registry Study on Genetics and Biomarkers of Acute Coronary Syndrome

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-02

Study Completion Date

2025-10-01

Brief Summary

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This is a national registry study to determine genetics risk factors and serial biomarkers of Acute Coronary Syndrome.

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Detailed Description

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Conditions

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Coronary Artery Disease Acute Coronary Syndrome Acute Myocardial Infarction Unstable Angina

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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case-ACS-MACE

ACS patients with poor prognosis

No interventions assigned to this group

control-ACS-MACE

ACS patients with good prognosis

No interventions assigned to this group

Health-control

general population without ACS

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Written informed consent has been provided.
* Contact Order Form has been provided.
* Aged 18 years or older.
* Hospitalized within 48 hours of onset of symptoms.
* Diagnosis of STEMI, NSTEMI or UA using the following definitions:

1.Criteria for STEMI diagnosis:
1. History of chest pain/discomfort and
2. Persistent ST-segment elevation (\> 30 min) of ≥ 0.1 mV in 2 or more contiguous ECG leads or presumed new left bundle branch block (LBBB) on admission and
3. Elevation of cardiac biomarkers (CK-MB, troponins): at least one value above the 99th percentile of the local laboratory upper reference limit.

2.Criteria for NSTEMI diagnosis:

1.History of chest pain/discomfort and 2.Lack of persistent ST-segment elevation, LBBB or intraventricular conduction disturbances and 3.Elevation of cardiac biomarkers (CK-MB, troponins): at least one value above the 99th percentile of the local laboratory upper reference limit. 3.Criteria for Unstable Angina diagnosis:
1. Symptoms of angina at rest or on minimal exercise and
2. At least 0.5mm ST deviation in at least 2 leads and
3. No increase in biomarkers of necrosis
4. OR objective evidence of ischaemia by non-invasive imaging OR significant coronary stenosis as determined by the treating physician at angiography if this is standard practice in study site.

* Age and gender are matched with cases.
* No Coronary Artery Disease was detected by Coronary CT examination.
* Normal biochemical indicators.

Exclusion Criteria

* UA, STEMI and NSTEMI precipitated by or as a complication of surgery, trauma, or GI bleeding or post-PCI.
* UA, STEMI and NSTEMI occurring in patients already hospitalized for other reasons.
* Presence of any condition/circumstance which in the opinion of the investigator could significantly limit the complete follow up of the patient (e.g. tourist, non-native speaker or does not understand the local language, psychiatric disturbances).
* Presence of serious/severe co-morbidities in the opinion of the investigator which may limit short term (i.e. 6 month) life expectancy.
* Current participation in a randomised interventional clinical trial.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes