Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Total Enrollment
124363 participants
Study Classification
OBSERVATIONAL
Study Start Date
2014-11-30
Study Completion Date
2020-12-31
Brief Summary
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To develop and implement quality improvement programs for the treatment of acute coronary syndrome (ACS) in China based on the successful experience of the AHA-Get with the Guidelines program. This program will use data collection, analysis, feedback, and process improvement to extend the use of evidence-based guidelines throughout the healthcare system and improve patient care of acute coronary syndrome.
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Detailed Description
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Conditions
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Acute Coronary Syndrome
Study Design
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Observational Model Type
CASE_ONLY
Study Time Perspective
RETROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Hospitalized patients with discharge diagnosis as acute coronary syndrome (including STEMI, NSTEMI and UAP) in 150 tertiary and 100 secondary hospitals.
Exclusion Criteria
None
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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American Heart Association
OTHER
Sponsor Role
collaborator
Chinese Society of Cardiology
OTHER
Sponsor Role
collaborator
Beijing Institute of Heart, Lung and Blood Vessel Diseases
OTHER
Sponsor Role
lead
Responsible Party
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Dong ZHAO
Principal Investigator
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
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Dong Zhao, Ph. D
Role: PRINCIPAL_INVESTIGATOR
Beijing Institute of Heart, Lung and Blood Vessel Diseases
Locations
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Beijing An Zhen Hospital
Beijing, , China
Site Status
Countries
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China
References
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Hao Y, Liu J, Liu J, Smith SC Jr, Huo Y, Fonarow GC, Ma C, Ge J, Taubert KA, Morgan L, Guo Y, Zhang Q, Wang W, Zhao D; CCC-ACS Investigators. Rationale and design of the Improving Care for Cardiovascular Disease in China (CCC) project: A national effort to prompt quality enhancement for acute coronary syndrome. Am Heart J. 2016 Sep;179:107-15. doi: 10.1016/j.ahj.2016.06.005. Epub 2016 Jun 18.
Reference Type
RESULT
Yang Q, Wang Y, Liu J, Liu J, Hao Y, Smith SC Jr, Huo Y, Fonarow GC, Ma C, Ge J, Taubert KA, Morgan L, Guo Y, Wang W, Zhou Y, Zhao D; CCC-ACS Investigators. Invasive Management Strategies and Antithrombotic Treatments in Patients With Non-ST-Segment-Elevation Acute Coronary Syndrome in China: Findings From the Improving CCC Project (Care for Cardiovascular Disease in China). Circ Cardiovasc Interv. 2017 Jun;10(6):e004750. doi: 10.1161/CIRCINTERVENTIONS.116.004750.
Reference Type
RESULT
Zhao G, Zhou M, Ma C, Huo Y, Smith SC Jr, Fonarow GC, Ge J, Han Y, Liu J, Hao Y, Liu J, Wang X, Taubert KA, Morgan L, Zhao D, Nie S; CCC-ACS Investigators. In-Hospital Outcomes of Dual Loading Antiplatelet Therapy in Patients 75 Years and Older With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Findings From the CCC-ACS (Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome) Project. J Am Heart Assoc. 2018 Mar 30;7(7):e008100. doi: 10.1161/JAHA.117.008100.
Reference Type
RESULT
Zhou M, Liu J, Hao Y, Liu J, Huo Y, Smith SC Jr, Ge J, Ma C, Han Y, Fonarow GC, Taubert KA, Morgan L, Yang N, Xing Y, Zhao D; CCC-ACS Investigators. Prevalence and in-hospital outcomes of diabetes among patients with acute coronary syndrome in China: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome Project. Cardiovasc Diabetol. 2018 Nov 27;17(1):147. doi: 10.1186/s12933-018-0793-x.
Reference Type
RESULT
Xing Y, Liu J, Hao Y, Liu J, Huo Y, Smith SC Jr, Ge J, Ma C, Han Y, Fonarow GC, Taubert KA, Morgan L, Yang N, Zhou M, Zhao D; CCC-ACS Investigators. Prehospital statin use and low-density lipoprotein cholesterol levels at admission in acute coronary syndrome patients with history of myocardial infarction or revascularization: Findings from the Improving Care for Cardiovascular Disease in China (CCC) project. Am Heart J. 2019 Jun;212:120-128. doi: 10.1016/j.ahj.2019.02.019. Epub 2019 Mar 13.
Reference Type
RESULT
Yang N, Liu J, Liu J, Hao Y, Huo Y, Smith SC Jr, Ge J, Ma C, Han Y, Fonarow GC, Taubert KA, Morgan L, Zhou M, Xing Y, Zhao D; CCC-ACS Investigators. Performance on management strategies with Class I Recommendation and A Level of Evidence among hospitalized patients with non-ST-segment elevation acute coronary syndrome in China: Findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) project. Am Heart J. 2019 Jun;212:80-90. doi: 10.1016/j.ahj.2019.02.012. Epub 2019 Mar 4.
Reference Type
RESULT
Hao Y, Liu J, Liu J, Yang N, Smith SC Jr, Huo Y, Fonarow GC, Ge J, Taubert KA, Morgan L, Zhou M, Xing Y, Ma CS, Han Y, Zhao D. Sex Differences in In-Hospital Management and Outcomes of Patients With Acute Coronary Syndrome. Circulation. 2019 Apr 9;139(15):1776-1785. doi: 10.1161/CIRCULATIONAHA.118.037655.
Reference Type
RESULT
Zhou Z, Xie H, Fan F, Yang F, Jiang J, Zheng B, Zhang Y, Hao Y, Liu J, Gong Y, Zhao D, Smith SC, Huo Y. Comparison of in-hospital net clinical outcomes of ticagrelor and clopidogrel in acute coronary syndrome patients stratified by CRUSADE score: findings from the CCC-ACS registry. Platelets. 2025 Dec;36(1):2570743. doi: 10.1080/09537104.2025.2570743. Epub 2025 Oct 27.
Reference Type
DERIVED
Zhou C, Zhang M, Zhao Z, Li E, Zhao Y, Luo W, Zheng K, Liu Y, Yin C, Zhang X, Gao H, Zhao D, Ma C. Clopidogrel vs. ticagrelor in ST-elevation myocardial infarction complicated by cardiogenic shock undergoing primary PCI : Findings from a National, multicenter registry. Thromb J. 2025 Apr 22;23(1):38. doi: 10.1186/s12959-025-00721-z.
Reference Type
DERIVED
Zhou C, Zhang M, Zhao Z, Li E, Zhao Y, Wang H, Luo W, Zheng K, Liu Y, Yin C, Zhang X, Gao H, Hou X, Zhao D, Ma C. Safety and efficacy of post-procedure anticoagulation in ST-elevation myocardial infarction complicated by cardiogenic shock undergoing primary percutaneous coronary intervention. BMC Cardiovasc Disord. 2025 Mar 28;25(1):231. doi: 10.1186/s12872-025-04639-2.
Reference Type
DERIVED
Zhang Y, Hao Y, Liu J, Yang N, Smith SC Jr, Huo Y, Fonarow GC, Ge J, Morgan L, Sun Z, Hu D, Yang Y, Ma CS, Zhao D, Han Y, Liu J, Zeng Y; CCC-ACS Investigators. Percutaneous coronary intervention in patients with acute coronary syndromes and increased platelet count. Arch Cardiovasc Dis. 2025 May;118(5):304-311. doi: 10.1016/j.acvd.2025.01.005. Epub 2025 Feb 13.
Reference Type
DERIVED
Zhao T, Wang J, Gu R, Sun D, Zheng L, Tian X, Han Y, Wang X; CCC-ACS investigators. Comparison of Multivessel Versus Culprit-Vessel-Only Revascularization in Patients With STEMI and Multivessel Disease During Primary PCI: In-Hospital Outcomes From the CCC-ACS Project in China. Catheter Cardiovasc Interv. 2025 Jan;105(1):43-53. doi: 10.1002/ccd.31332. Epub 2024 Dec 10.
Reference Type
DERIVED
Yang N, Zhao W, Hao Y, Liu J, Liu J, Zhao X, Yan Y, Nie S, Gong W; CCC investigators. Incidence and risk factors for cardiac rupture after ST-segment elevation myocardial infarction in contemporary era: findings from the improving care for cardiovascular disease in China-Acute Coronary Syndrome project. Intern Emerg Med. 2025 Jan;20(1):77-85. doi: 10.1007/s11739-024-03746-w. Epub 2024 Oct 27.
Reference Type
DERIVED
Gong W, Yan Y, Liu J, Wang X, Zheng W, Que B, Ai H, Smith SC Jr, Fonarow GC, Morgan L, Zhao D, Ma C, Han Y, Nie S; CCC-ACS Investigators. In-Hospital Mortality and Treatment in Patients With Acute Coronary Syndrome With and Without Standard Modifiable Cardiovascular Risk Factors: Findings From the CCC-ACS Project. J Am Heart Assoc. 2024 Oct;13(19):e029252. doi: 10.1161/JAHA.122.029252. Epub 2024 Sep 18.
Reference Type
DERIVED
Zhang T, Wang X, Zhang Y, Feng T, Zhou Y, Zhao L. Early beta-blocker use and in-hospital outcomes in patients with chronic obstructive pulmonary disease hospitalized with acute coronary syndrome: findings from the CCC-ACS project. Front Cardiovasc Med. 2024 Jul 11;11:1385943. doi: 10.3389/fcvm.2024.1385943. eCollection 2024.
Reference Type
DERIVED
Zhao G, Zhou M, Zhao X, Ma C, Han Y, Liu J, Zhao D, Nie S; CCC-ACS Investigators. Characteristics, Treatment, and In-Hospital Outcomes of Older Patients With STEMI Without Standard Modifiable Risk Factors. JACC Asia. 2023 Nov 21;4(1):73-83. doi: 10.1016/j.jacasi.2023.09.013. eCollection 2024 Jan.
Reference Type
DERIVED
Zhu J, Liu W, Li J, Ma C, Zhao D. A Small Increase in Serum Creatinine within 48 h of Hospital Admission Is an Independent Predictor of In-Hospital Adverse Outcomes in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Findings from the Improving Care for Cardiovascular Disease in the China Project. Cardiol Res Pract. 2023 Mar 28;2023:1374206. doi: 10.1155/2023/1374206. eCollection 2023.
Reference Type
DERIVED
Wang Y, Geng Y, Zhang O, Xu Q, Xue Y, Zhou B, Zhang P; CCC-ACS Investigators. Association between P2Y12 inhibitor reloading and in-hospital outcomes for patients with non-ST-segment elevation acute coronary syndrome already on chronic P2Y12 receptor inhibitors therapy in China: findings from the CCC-ACS (improving care for cardiovascular disease in China-acute coronary syndrome) project. Eur J Med Res. 2023 Feb 2;28(1):59. doi: 10.1186/s40001-023-01025-6.
Reference Type
DERIVED
Li Z, Sun H, Hao Y, Liu H, Jin Z, Li L, Zhang C, Ma M, Teng T, Chen X, Shen Y, Yu Y, Liu J, Richards AM, Tan HC, Zhao D, Zhou X, Yang Q. Renin-angiotensin system inhibition and in-hospital mortality in acute coronary syndrome patients with advanced renal dysfunction: findings from CCC-ACS project and a nationwide electronic health record-based cohort in China. Eur Heart J Qual Care Clin Outcomes. 2023 Dec 22;9(8):785-795. doi: 10.1093/ehjqcco/qcad006.
Reference Type
DERIVED
Yang Y, Hao Y, Liu J, Yang N, Hu D, Sun Z, Zhao D, Liu J; Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) Investigators. Practice of reperfusion in patients with ST-segment elevation myocardial infarction in China: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome project. Chin Med J (Engl). 2022 Dec 5;135(23):2821-2828. doi: 10.1097/CM9.0000000000002257.
Reference Type
DERIVED
Yang N, Liu J, Liu J, Hao Y, Smith JSC, Huo Y, Fonarow GC, Ge J, Morgan L, Ma C, Han Y, Zhao D; Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) project investigators. In-hospital outcomes of ticagrelor versus clopidogrel in patients 75 years or older with acute coronary syndrome: findings from the Improving Care for Cardiovascular Disease in China (CCC)-Acute Coronary Syndrome Project. Age Ageing. 2022 Nov 1;51(11):afac231. doi: 10.1093/ageing/afac231.
Reference Type
DERIVED
Gong W, Yan Y, Wang X, Zheng W, Smith SC Jr, Fonarow GC, Morgan L, Liu J, Zhao D, Ma C, Han Y, Montalescot G, Nie S; CCC-ACS Investigators. Risk Factors for In-Hospital Cardiac Arrest in Patients With ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol. 2022 Nov 8;80(19):1788-1798. doi: 10.1016/j.jacc.2022.08.797.
Reference Type
DERIVED
Wang Y, Yang N, Suo M, Liu X, Wang Z, Zhang X, Liu J, Zhao D, Wu X; CCC-ACS Investigators. In-hospital outcomes of Ticagrelor versus Clopidogrel in high bleeding risk patients with acute coronary syndrome: Findings from the CCC-ACS project. Thromb Res. 2022 Aug;216:43-51. doi: 10.1016/j.thromres.2022.04.004. Epub 2022 May 10.
Reference Type
DERIVED
Xu S, Li Z, Yang T, Li L, Song X, Hao Y, Smith SC, Fonarow GC, Morgan L, Liu J, Liu J, Zhao D, Yang Q, Zhou X, Li Y. Association between Early Oral beta-Blocker Therapy and Risk for In-Hospital Major Bleeding after Percutaneous Coronary Intervention for Acute Coronary Syndrome: Findings from CCC-ACS Project. Eur Heart J Qual Care Clin Outcomes. 2022 Jun 17:qcac036. doi: 10.1093/ehjqcco/qcac036. Online ahead of print.
Reference Type
DERIVED
Lin YW, Huang JL, Wei XB, Jiang M, Ran P, Li J, Qiu J, Zhong Q, Zhou YL, Chen JY, Yu DQ. Estimated glomerular filtration rate derived from different formulas and prognosis in acute coronary syndrome: Findings from the improving care for cardiovascular disease in China-acute coronary syndrome project. Am J Med Sci. 2022 Nov;364(5):565-574. doi: 10.1016/j.amjms.2021.10.034. Epub 2022 Jun 2.
Reference Type
DERIVED
Yang JQ, Ran P, Li J, Zhong Q, Smith SC Jr, Wang Y, Fonarow GC, Qiu J, Morgan L, Wei XB, Chen XB, Huang JL, Hao YC, Zhou YL, Siu CW, Zhao D, Chen JY, Yu DQ. A Risk Stratification Scheme for In-Hospital Cardiogenic Shock in Patients With Acute Myocardial Infarction. Front Cardiovasc Med. 2022 Mar 4;9:793497. doi: 10.3389/fcvm.2022.793497. eCollection 2022.
Reference Type
DERIVED
Zhou M, Zhang J, Liu J, Smith SC Jr, Ma C, Ge J, Huo Y, Fonarow GC, Liu J, Hao Y, Gao F, Sun Y, Morgan L, Yang N, Hu G, Zeng Y, Han Y, Zhao D; CCC-ACS Investigators. Proton Pump Inhibitors and In-Hospital Gastrointestinal Bleeding in Patients With Acute Coronary Syndrome Receiving Dual Antiplatelet Therapy. Mayo Clin Proc. 2022 Apr;97(4):682-692. doi: 10.1016/j.mayocp.2021.11.037. Epub 2022 Feb 12.
Reference Type
DERIVED
Wang X, Zhao G, Zhou M, Ma C, Ge J, Huo Y, Smith SC Jr, Fonarow GC, Hao Y, Liu J, Morgan L, Gong W, Yan Y, Liu J, Zhao D, Han Y, Nie S. Trends in Bleeding Events Among Patients With Acute Coronary Syndrome in China, 2015 to 2019: Insights From the CCC-ACS Project. Front Cardiovasc Med. 2021 Dec 13;8:769165. doi: 10.3389/fcvm.2021.769165. eCollection 2021.
Reference Type
DERIVED
Yang Q, Sun D, Pei C, Zeng Y, Wang Z, Li Z, Hao Y, Song X, Li Y, Liu G, Tang Y, Smith SC, Han Y, Huo Y, Ge J, Ma C, Fonarow GC, Morgan L, Liu J, Liu J, Zhou M, Zhao D, Zhou Y, Zhou X; CCC-ACS Investigators. LDL cholesterol levels and in-hospital bleeding in patients on high-intensity antithrombotic therapy: findings from the CCC-ACS project. Eur Heart J. 2021 Aug 31;42(33):3175-3186. doi: 10.1093/eurheartj/ehab418.
Reference Type
DERIVED
Yang L, Ye N, Wang G, Bian W, Xu F, Zhao D, Liu J, Hao Y, Liu J, Yang N, Cheng H; CCC-ACS. The association between atrial fibrillation and in-hospital outcomes in chronic kidney disease patients with acute coronary syndrome: findings from the improving care for cardiovascular disease in China-acute coronary syndrome (CCC-ACS) project. BMC Cardiovasc Disord. 2021 Jul 17;21(1):345. doi: 10.1186/s12872-021-02125-z.
Reference Type
DERIVED
Ran P, Yang JQ, Li J, Li G, Wang Y, Qiu J, Zhong Q, Wang Y, Wei XB, Huang JL, Siu CW, Zhou YL, Zhao D, Yu DQ, Chen JY. A risk score to predict in-hospital mortality in patients with acute coronary syndrome at early medical contact: results from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) Project. Ann Transl Med. 2021 Jan;9(2):167. doi: 10.21037/atm-21-31.
Reference Type
DERIVED
Zhao X, Kang Y, Wang X, Yang X, Ai G, Liu Y, Xu P, Zhang J, Gu C, Zhang Y, Hao Y, Zhao D, Han Y; CCC investigators. Clinical significance of glycated hemoglobin in acute coronary syndrome patients from the CCC-ACS project : Findings from a multicenter retrospective observational study. Herz. 2021 Sep;46(Suppl 2):287-294. doi: 10.1007/s00059-020-04999-9. Epub 2020 Nov 24.
Reference Type
DERIVED
Hu G, Zhou M, Liu J, Smith SC Jr, Ma C, Ge J, Huo Y, Fonarow GC, Hao Y, Liu J, Taubert KA, Morgan L, Yang N, Zeng Y, Han Y, Zhao D; CCC-ACS Investigators. Smoking and Provision of Smoking Cessation Interventions among Inpatients with Acute Coronary Syndrome in China: Findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome Project. Glob Heart. 2020 Oct 23;15(1):72. doi: 10.5334/gh.784.
Reference Type
DERIVED
Ye N, Yang L, Wang G, Bian W, Xu F, Ma C, Zhao D, Liu J, Hao Y, Liu J, Yang N, Cheng H; CCC-ACS. Admission fasting plasma glucose is associated with in-hospital outcomes in patients with acute coronary syndrome and diabetes: findings from the improving Care for Cardiovascular Disease in China - Acute Coronary Syndrome (CCC-ACS) project. BMC Cardiovasc Disord. 2020 Aug 20;20(1):380. doi: 10.1186/s12872-020-01662-3.
Reference Type
DERIVED
Other Identifiers
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CCC-ACS-2014
Identifier Type: -
Identifier Source: org_study_id
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