Inflammation and Acute Coronary Syndromes

NCT ID: NCT01000701

Last Updated: 2016-09-09

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 4000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2009-10-31
• Study Completion Date: 2019-01-31

Brief Summary

Subproject 1: Optimize prevention after acute coronary syndromes (ACS) by improving caregiver and patient education (http://elips.hug-ge.ch/eng/index_eng2.htm)

Subproject 2: Discover novel genomic biomarkers of ACS in leukocyte subsets by means of analyzing gene expression profiles and function

Subproject 3: Evaluate novel diagnostic and prognostic biomarkers in soluble form in blood/plasma and urine

Subproject 5: Visualize the vulnerable plaque using intravascular ultrasound/optical coherence tomography (IVUS/OCT) and correlate with outcome and biomarkers

Subproject 7: Characterize the effects of inflammation on progenitor/stem cell-mediated repair after ACS by means of analyzing gene expression profiles and function

Conditions

Acute Coronary Syndromes

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• All patients with age ≥ 18 years presenting within 5 days (preferably within 72 hours) after pain onset with the main diagnosis of ACS (acute myocardial infarction: STEMI /NSTEMI and threatened infarction: unstable angina pectoris), who enter the hospital: The patients show symptoms, which are compatible with angina pectoris (chest pain, dyspnoea) and at least one of the following characteristics:

• persistent ST-segment elevation or depression, T inversion or dynamic ECG changes, new left bundle branch block (LBBB)
• Evidence of positive troponin by local laboratory reference values with a rise and/or fall in serial troponin levels
• known coronary artery disease, specified as status after myocardial infarction, CABG, or PCI or newly documented ≥50% stenosis of an epicardial coronary artery during the initial catheterization

Exclusion Criteria

• Severe physical disability,
• Dementia (inability to comprehend study), OR
• Less than 1 year of life expectancy (for non-cardiac reasons).

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Bern

OTHER

Sponsor Role: collaborator

University Hospital, Geneva

OTHER

Sponsor Role: collaborator

University of Lausanne Hospitals

OTHER

Sponsor Role: collaborator

University of Zurich

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

University Hospital, Geneva

Geneva, Canton of Geneva, Switzerland

Site Status: RECRUITING

University Hospital, Bern

Bern, , Switzerland

Site Status: RECRUITING

University Hospital, Lausanne

Lausanne, , Switzerland

Site Status: RECRUITING

University Hospital, Zurich

Zurich, , Switzerland

Site Status: RECRUITING

Countries

Switzerland

Central Contacts

Thomas F Luscher, MD

Role: CONTACT

cardiotfl@gmx.ch

0041 44 255 ext. 2121

Christian M Matter, MD

Role: CONTACT

christian.matter@uzh.ch

0041 44 635 ext. 6467

Facility Contacts

François Mach, MD

Role: primary

francois.mach@hcuge.ch

Pierre-Frederic Keller, MD

Role: backup

Stephan Windecker, MD

Role: primary

stephan.windecker@insel.ch

Nicolas Rodondi, MD

Role: primary

nicolas.rodondi@insel.ch

Thomas F Luscher, MD

Role: primary

cardiotfl@gmx.ch

References

van der Stouwe JG, Godly K, Kraler S, Godly J, Matter CM, Wenzl FA, von Eckardstein A, Raber L, Mach F, Obeid S, Templin C, Luscher TF, Niederseer D; SPUM-ACS investigators. Body temperature, systemic inflammation and risk of adverse events in patients with acute coronary syndromes. Eur J Clin Invest. 2024 Dec;54(12):e14314. doi: 10.1111/eci.14314. Epub 2024 Sep 30.

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PMID: 39350322 (View on PubMed)

Davies A, Wenzl FA, Li XS, Winzap P, Obeid S, Klingenberg R, Mach F, Raber L, Muller O, Matter CM, Laaksonen R, Wang Z, Hazen SL, Luscher TF. Short and medium chain acylcarnitines as markers of outcome in diabetic and non-diabetic subjects with acute coronary syndromes. Int J Cardiol. 2023 Oct 15;389:131261. doi: 10.1016/j.ijcard.2023.131261. Epub 2023 Aug 11.

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PMID: 37574027 (View on PubMed)

Bruno F, Adjibodou B, Obeid S, Kraler SC, Wenzl FA, Akhtar MM, Denegri A, Roffi M, Muller O, von Eckardstein A, Raber L, Templin C, Luscher TF. Occlusion of the infarct-related coronary artery presenting as acute coronary syndrome with and without ST-elevation: impact of inflammation and outcomes in a real-world prospective cohort. Eur Heart J Qual Care Clin Outcomes. 2023 Sep 12;9(6):564-574. doi: 10.1093/ehjqcco/qcad027.

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Gilgien-Denereaz L, Jakob J, Tal K, Gencer B, Carballo D, Raber L, Klingenberg R, Matter CM, Sudano I, Luscher TF, Windecker S, Muller O, Fournier S, Rodondi N, Mach F, Auer R, Nanchen D. Long-term effects of systematic smoking cessation counselling during acute coronary syndrome, a multicentre before-after study. Swiss Med Wkly. 2022 Jul 18;152:w30209. doi: 10.4414/smw.2022.w30209. eCollection 2022 Jul 18.

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PMID: 35567560 (View on PubMed)

Klingenberg R, Aghlmandi S, Raber L, Akhmedov A, Gencer B, Carballo D, Nanchen D, Bucher HC, Rodondi N, Mach F, Windecker S, Landmesser U, von Eckardstein A, Hamm CW, Luscher TF, Matter CM. Cysteine-Rich Angiogenic Inducer 61 Improves Prognostic Accuracy of GRACE (Global Registry of Acute Coronary Events) 2.0 Risk Score in Patients With Acute Coronary Syndromes. J Am Heart Assoc. 2021 Oct 19;10(20):e020488. doi: 10.1161/JAHA.120.020488. Epub 2021 Oct 8.

Reference Type: DERIVED

PMID: 34622666 (View on PubMed)

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Reference Type: DERIVED

PMID: 34015112 (View on PubMed)

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Reference Type: DERIVED

PMID: 33624028 (View on PubMed)

Winzap P, Davies A, Klingenberg R, Obeid S, Roffi M, Mach F, Raber L, Windecker S, Templin C, Nietlispach F, Nanchen D, Gencer B, Muller O, Matter CM, von Eckardstein A, Luscher TF. Diabetes and baseline glucose are associated with inflammation, left ventricular function and short- and long-term outcome in acute coronary syndromes: role of the novel biomarker Cyr 61. Cardiovasc Diabetol. 2019 Oct 31;18(1):142. doi: 10.1186/s12933-019-0946-6.

Reference Type: DERIVED

PMID: 31672144 (View on PubMed)

Koskinas KC, Zanchin T, Klingenberg R, Gencer B, Temperli F, Baumbach A, Roffi M, Moschovitis A, Muller O, Tuller D, Stortecky S, Mach F, Luscher TF, Matter CM, Pilgrim T, Heg D, Windecker S, Raber L. Incidence, Predictors, and Clinical Impact of Early Prasugrel Cessation in Patients With ST-Elevation Myocardial Infarction. J Am Heart Assoc. 2018 Apr 13;7(8):e008085. doi: 10.1161/JAHA.117.008085.

Reference Type: DERIVED

PMID: 29654204 (View on PubMed)

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Reference Type: DERIVED

PMID: 28029055 (View on PubMed)

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PMID: 24676282 (View on PubMed)

Related Links

http://www.spum-acs.ch

Related Info

Other Identifiers

SPUM-ACS

Identifier Type: -

Identifier Source: org_study_id