Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

403 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-03-31

Study Completion Date

2010-12-31

Brief Summary

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The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk stratification in patients presenting with acute chest pain at the emergency department.

Study hypothesis: MRP 8/14, alone or together with other established or new biomarkers, increases the earliness, sensitivity, and specificity of diagnosing acute coronary syndromes.

Detailed Description

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Conditions

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Myocardial Ischemia Acute Coronary Syndrome Myocardial Infarction Coronary Occlusion Coronary Thrombosis

Keywords

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Acute Coronary Syndrome Myocardial Infarction Coronary Artery Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* All patients in the emergency department of the University Hospital Zurich with measurement of troponin during the routine diagnostic evaluation.

Exclusion Criteria

* Refusal or inability to give informed consent.

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Willibald Maier, MD

Role: PRINCIPAL_INVESTIGATOR

Cardiology, University Hospital Zurich

Locations

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Cardiology, University Hospital

Zurich, , Switzerland

Site Status

Countries

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Switzerland

References

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Altwegg LA, Neidhart M, Hersberger M, Muller S, Eberli FR, Corti R, Roffi M, Sutsch G, Gay S, von Eckardstein A, Wischnewsky MB, Luscher TF, Maier W. Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes. Eur Heart J. 2007 Apr;28(8):941-8. doi: 10.1093/eurheartj/ehm078. Epub 2007 Mar 26.

Reference Type BACKGROUND

PMID: 17387139 (View on PubMed)

Other Identifiers

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MyRiAD

Identifier Type: -

Identifier Source: org_study_id