RNA as Prognostic Biomarkers in Patients With Acute Coronary Syndrome
NCT ID: NCT06058182
Last Updated: 2023-10-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
70 participants
OBSERVATIONAL
2020-07-13
2027-01-30
Brief Summary
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Detailed Description
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In particular, will be to verify whether there are circulating transcripts in peripheral blood, coding or not for proteins (mRNAs or ncRNAs), modulated differently in patients with ACS (ACS\_signature) undergoing PCI, distinguished on the basis of evolution towards ventricular dysfunction. The study will be based on whole genome transcriptomic analysis.
Conditions
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Study Design
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OTHER
PROSPECTIVE
Interventions
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blood draws
Pre-procedure, post-procedure (12-24 h), 6-month, and 12-month blood draws
Eligibility Criteria
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Inclusion Criteria
2. Patients with ACS (first episode), defined according to the guidelines of the European Society of Cardiology (ESC) 2017
3. Indication for percutaneous revascularization treatment
4. Informed consent to study enrollment
Exclusion Criteria
2. Previous cardiac surgery including coronary artery bypass grafts
3. Total chronic occlusions
4. Patients with known hypersensitivity or contraindication to any of the following drugs:
* heparin
* aspirin,
* clopidogrel,
* ticlopidine,
* sirolimus,
* everolimus.
5. Any contraindication to drug-eluting stent implantation (DES)
6. Patients with a documented history of myocardial infarction;
7. Left ventricular ejection fraction (LVEF) \<30% before PCI
8. Patients in cardiogenic shock
9. Patients with advanced ST-segment elevation myocardial infarction (\> 48 h from onset of symptoms/Q waves on electrocardiogram) or undergoing fibrinolysis;
10. Patients with prior known cardiomyopathy with LVEF \< 40%
11. Patients with malignant neoplasm or systemic disease with quoad vitam prognosis less than 1 year;
12. Patients with known active infectious diseases;
13. Patients who are unable to express valid informed consent to the act of enlistment
14. Pregnant women
18 Years
ALL
No
Sponsors
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IRCCS Policlinico S. Donato
OTHER
Responsible Party
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Luca Testa
Principal investigator
Locations
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IRCCS Policlinico S. Donato, Milan, Italy
Milan, Milan, Italy
Countries
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Central Contacts
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Facility Contacts
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Provided Documents
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Document Type: Study Protocol
Document Type: Informed Consent Form
Other Identifiers
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RNA_ACS
Identifier Type: -
Identifier Source: org_study_id
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