Angiography Derived Index of Microcirculatory Resistance in Patients With Acute Myocardial Infarction

NCT ID: NCT05696379

Last Updated: 2023-01-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

5000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-06-01

Study Completion Date

2022-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of acute myocardial infarction (AMI) patients, and has been shown to be associated with poor prognosis. Angiography derived index of micro-circulatory resistance (Angio-IMR) is a novel pressure-wire free approach to assess coronary microvascular disease with great diagnostic performance. The current study will further investigate the prognostic value of Angio-IMR in patients with AMI in multicenter retrospective cohort.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Myocardial Infarction (AMI)

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

STEMI with high Angio-IMR

Patients with ST segment elevation myocardial infarction and high Angio-IMR

Angiography derived index of micro-circulatory resistance (Angio-IMR)

Intervention Type OTHER

Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.

STEMI with low Angio-IMR

Patients with ST segment elevation myocardial infarction and low Angio-IMR

Angiography derived index of micro-circulatory resistance (Angio-IMR)

Intervention Type OTHER

Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.

NSTEMI with high Angio-IMR

Patients with non-ST segment elevation myocardial infarction and high Angio-IMR

Angiography derived index of micro-circulatory resistance (Angio-IMR)

Intervention Type OTHER

Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.

NSTEMI with low Angio-IMR

Patients with non-ST segment elevation myocardial infarction and low Angio-IMR

Angiography derived index of micro-circulatory resistance (Angio-IMR)

Intervention Type OTHER

Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Angiography derived index of micro-circulatory resistance (Angio-IMR)

Angiography derived index of micro-circulatory resistance (Angio-IMR) post percutaneous coronary intervention.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Acute myocardial infarction patients who underwent successful percutaneous coronary intervention

Exclusion Criteria

* No appropriate coronary angiography images (inferior image quality, image loss, severe arteries overlap, or significant artifact)
* Previous coronary artery bypass graft
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Shengjing Hospital

OTHER

Sponsor Role collaborator

RenJi Hospital

OTHER

Sponsor Role collaborator

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Second Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

Site Status

Countries

Review the countries where the study has at least one active or historical site.

China

References

Explore related publications, articles, or registry entries linked to this study.

Chen Z, Zhang Y, Fang J, Zheng Y, Chen D, Yidilisi A, Zhang X, Liu C, Huang J, Ji R, Chen J, Chen G, Lin P, Hu Y, Xiang J, Wang J, Jiang J. Thorough Physiological Assessment in Non-Culprit Vessels of Patients with Acute Myocardial Infarction: Is It a Required Action? Cardiovasc Drugs Ther. 2025 Sep 6. doi: 10.1007/s10557-025-07768-0. Online ahead of print.

Reference Type DERIVED
PMID: 40913743 (View on PubMed)

Chen D, Zhang Y, Yidilisi A, Hu D, Zheng Y, Fang J, Gong Q, Huang J, Dong Q, Pu J, Niu T, Xiang J, Wang J, Jiang J. Combined risk estimates of diabetes and coronary angiography-derived index of microcirculatory resistance in patients with non-ST elevation myocardial infarction. Cardiovasc Diabetol. 2024 Aug 16;23(1):300. doi: 10.1186/s12933-024-02400-1.

Reference Type DERIVED
PMID: 39152477 (View on PubMed)

Zhang Y, Pu J, Niu T, Fang J, Chen D, Yidilisi A, Zheng Y, Lu J, Hu Y, Koo BK, Xiang J, Wang J, Jiang J. Prognostic Value of Coronary Angiography-Derived Index of Microcirculatory Resistance in Non-ST-Segment Elevation Myocardial Infarction Patients. JACC Cardiovasc Interv. 2024 Aug 26;17(16):1874-1886. doi: 10.1016/j.jcin.2024.04.048. Epub 2024 Aug 7.

Reference Type DERIVED
PMID: 39115479 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2022-0878

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.