A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)
NCT ID: NCT05793567
Last Updated: 2025-08-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
52 participants
OBSERVATIONAL
2026-08-31
2027-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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T2MI Patients
Patients with T2MI and no epicardial coronary stenosis \>50% will be prospectively enrolled and undergo a routine standard of care coronary angiogram with coronary reactivity testing (CRT).
Coronary angiogram with coronary reactivity testing (CRT)
CRT is an angiography procedure (using X-ray) to examine the small blood vessels in the heart and how they respond to three drugs (adenosine, acetylcholine and nitroglycerin) as per clinical protocol.
Controls
Patients with atypical chest pain and no obstructive disease on coronary angiogram who have been referred for investigation of suspected CMD and have a clinical indication for CMD testing will be retrospectively enrolled and data collected from a previous routine standard of care coronary angiogram with coronary reactivity testing (CRT) will be utilized.
No interventions assigned to this group
Interventions
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Coronary angiogram with coronary reactivity testing (CRT)
CRT is an angiography procedure (using X-ray) to examine the small blood vessels in the heart and how they respond to three drugs (adenosine, acetylcholine and nitroglycerin) as per clinical protocol.
Eligibility Criteria
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Inclusion Criteria
* Structurally normal heart (normal LV and RV function, no more than mild valvular heart disease)
* For controls: atypical chest pain with indication for CMD testing
* For T2MI: meet criteria for T2MI according to the 4th Universal definition of MI (rise/fall of troponin with at least 1 value \>99th centile+ evidence of symptoms or signs of myocardial ischemia)
Exclusion Criteria
* Known to have angiographically significant CAD/pressure wire positive for epicardial CAD
* Inability to receive heparin products
* Allergy/contraindication to acetylcholine/adenosine/nitroglycerine products
* Prior coronary artery bypass grafting
* Pregnancy (if sexually active woman of reproductive age, need negative pregnancy test prior to proceeding with coronary angiography - this is standard of care in cath lab)
* Asthma with prior ICU admission due to bronchospasm/need for invasive ventilation
18 Years
ALL
No
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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Claire E. Raphael
Principal Investigator
Principal Investigators
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Claire Raphael, MBBS, PhD.
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic Rochester
Rochester, Minnesota, United States
Countries
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Central Contacts
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Ischemic Heart Disease Research Team
Role: CONTACT
Facility Contacts
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Ischemic Heart Disease Research Team
Role: primary
Related Links
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Mayo Clinic Clinical Trials
Other Identifiers
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22-012721
Identifier Type: -
Identifier Source: org_study_id
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