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Prediction of Coronary Artery Disease Severity by Epicardial Adipose Tissue Thickness

NCT ID: NCT03308539

Last Updated: 2017-10-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-01

Study Completion Date

2018-09-01

Brief Summary

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is to test the hypotheses that epicardial adipose tissue can be a marker of severity of coronary artery disease in myocardial infarction patients

Detailed Description

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epicardial adipose tissue is defined as the adipose tissue between the visceral pericardium and the outer margin of the myocardium which can be considered an endocrine organ that secretes pro-inflammatory and anti-inflammatory cytokines and chemokines including adiponectin.as investigators know, inflammatory response is an important factor in the coronary atherogenesis. Therefore,epicardial adipose tissue is likely to be connected with the severity of coronary artery disease.Recent studies showed that the thickness of the epicardial adipose tissue in patients with coronary artery disease was greater than that with normal coronary arteries.

epicardial adipose tissue will be assessed using transthoracic echocardiography and cardiac magnetic resonance which allows for an accurate volumetric quantification of epicardial fat.

Conditions

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Myocardial Infarction

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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myocardial infarction patients

transthoracic echocardiography and cardiac magnetic resonance

echocardiography and cardiac magnetic resonance

Intervention Type RADIATION

transthoracic echocardiography and magnetic resonance imaging of the heart

Interventions

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echocardiography and cardiac magnetic resonance

transthoracic echocardiography and magnetic resonance imaging of the heart

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

1. Normal thoracic shape
2. Sinus rhythm
3. without severe respiratory diseases

Exclusion Criteria

1. contraindication for cardiac magnetic resonance.
2. Patients who previously underwent coronary artery bypass grafting or percutaneous coronary angiography prior to admission
3. history of chronic kidney disease with glomerular filtration rate \<30 mL/min
4. pericardial and/or pleural effusion.
Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Osama Fekry

OTHER

Sponsor Role lead

Responsible Party

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Osama Fekry

principal investigator

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Jacqueline George

Asyut, Single, Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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jacqueline george, master

Role: CONTACT

Phone: 01275502685

Email: [email protected]

hosam hassan el araby, pofessor

Role: CONTACT

Phone: 01223971327

Email: [email protected]

Facility Contacts

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hosam hassan, professor doctor

Role: primary

heba el nagar, lecturer

Role: backup

References

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Desferrioxamine and transfusional iron overload. Lancet. 1978 Mar 4;1(8062):479-80. No abstract available.

Reference Type RESULT
PMID: 76025 (View on PubMed)

Other Identifiers

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epicardial adipose tissue

Identifier Type: -

Identifier Source: org_study_id