Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium
NCT ID: NCT06527807
Last Updated: 2024-08-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
1200 participants
OBSERVATIONAL
2024-07-31
2025-06-30
Brief Summary
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This study is divided into three parts. The first part is a case-control study to explore the risk factors of ASPP and the predictors of the prognosis of ASPP patients. The second part is a cohort study to evaluate the impact of ASPP on the risk of recurrent stroke. The third part is a cohort study to assess the impact of ASPP on the short-term and long-term outcomes of their offsprings by comparing the offsprings of ASPP patients with the offsprings of non-ASPP participants.
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Detailed Description
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Conditions
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Study Design
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OTHER
RETROSPECTIVE
Study Groups
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ASPP
Patients with acute stroke in pregnancy or puerperium
No interventions assigned to this group
Pregnant/Puerperal Non-Stroke
Pregnant or puerperal participants without any history of stroke
No interventions assigned to this group
Non-Pregnant Stroke
Non-pregnant or non-puerperal participants with a recent acute stroke event
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
2. Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written informed consent.
1. Female patients ≥18 years of age;
2. Patients in pregnancy or within 6 weeks postpartum;
3. Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written informed consent.
Exclusion Criteria
2. Patients missing critical baseline demographic, clinical or neuroimaging data.
2\. Cohort Study on Offspring Outcomes:
1. Patients or their legally acceptable representatives or relatives refuse follow-up;
2. Patients missing critical baseline demographic, clinical or neuroimaging data;
3. Patients whose offsprings have congenital malformation or inborn error of metabolism;
4. Patients with complications which may affect cerebral blood flow supply, such as amniotic fluid embolism, in pregnancy;
5. Patients whose family members other than the parents and siblings of their offsprings have a history of severe mental illness, such as mental retardation, autism and schizophrenia;
6. Patients undergo acute myocardial infarction in pregnancy;
7. Patients undergo non-spontaneous stroke events due to other causes, such as cerebral infarction or hemorrhage caused by surgery.
FEMALE
No
Sponsors
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Affiliated Hospital of Jiangnan University
OTHER
Affiliated Hospital of Nantong University
OTHER
Baotou Central Hospital
OTHER
First Affiliated Hospital of Harbin Medical University
OTHER
First Affiliated Hospital Xi'an Jiaotong University
OTHER
Jiangyin People's Hospital
OTHER
Qianfoshan Hospital
OTHER
RenJi Hospital
OTHER
Second Affiliated Hospital of Soochow University
OTHER
Second Hospital of Shanxi Medical University
OTHER
Shanxi Bethune Hospital
OTHER
Shenzhen Second People's Hospital
OTHER
The Affiliated Hospital of Qingdao University
OTHER
The First Affiliated Hospital of Nanchang University
OTHER
The First Affiliated Hospital of University of Science and Technology of China
OTHER
The First Affiliated Hospital of Zhengzhou University
OTHER
The Second Affiliated Hospital of Hainan Medical University
OTHER
Lanzhou University Second Hospital
OTHER
Tianjin Huanhu Hospital
OTHER
Tianjin Medical University General Hospital
OTHER
West China Hospital
OTHER
Xiangya Hospital of Central South University
OTHER
Xinxiang Central Hospital
OTHER
Zhejiang Provincial People's Hospital
OTHER
Binzhou Medical University
OTHER
Chongqing Medical University
OTHER
Tibetan Second People's Hospital
UNKNOWN
Beijing Tiantan Hospital
OTHER
Responsible Party
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Principal Investigators
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Xingju Liu, MD
Role: PRINCIPAL_INVESTIGATOR
Beijing Tiantan Hospital
Jizong Zhao, MD
Role: STUDY_CHAIR
Beijing Tiantan Hospital
Locations
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Beijing Tiantan hospital
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Facility Contacts
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References
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Zhang Z, Yin Z, Liu T, Zhang X, Zhang Q, Lu J, Mu L, Dong Y, Liu J, Xiao Y, Chen Y, Song C, Wang Z, Liu Y, Ding W, Zhang L, Shi H, Qi J, Tang B, Wang F, Guo P, Tang Y, Yu M, Zheng W, He Q, Yu J, Zhu A, Fang D, Li G, Bai Y, Zhang Y, Li J, Wang Y, Gao F, Ma Y, Liu Y, Ma L, Yang B, Zhao Y, Ye X, Zhang Q, Zhang Y, Liu X, Zhao J; ASPP Study Group. Clinical characteristics and prognosis of acute stroke in pregnancy and puerperium (ASPP) patients and their offspring: a retrospective, observational, nationwide, multicenter study protocol. Chin Neurosurg J. 2025 Jun 4;11(1):11. doi: 10.1186/s41016-025-00396-5.
Other Identifiers
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KY2024-180-01
Identifier Type: -
Identifier Source: org_study_id
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