Cardiovascular Risk After Preeclampsia

NCT ID: NCT05277233

Last Updated: 2024-07-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-04

Study Completion Date

2026-04-30

Brief Summary

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Investigation of cardiovascular risk 5-15 years after early or late-onset preeclampsia by adenosine stress Magnetic Resonance Imaging and non-invasive methods like retinal vessel analysis, skin measurement of advanced glycation end products, flow-mediated dilation or pulse wave analysis in comparison to women after healthy pregnancies.

Detailed Description

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Conditions

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Preeclampsia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Study Groups

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Early-onset preeclampsia

Defined as preeclampsia that develops before 34 weeks of gestation

No interventions assigned to this group

Late-onset preeclampsia

Defined as preeclampsia that develops after 34 weeks of gestation

No interventions assigned to this group

Control

Healthy pregnancies, matched to early and late-onset cases

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Women
* 18-60 years
* 5-15 years postpartum

Exclusion Criteria

* Atrioventricular block, chronic obstructive pulmonary disease, bronchial asthma
* Pregnancy and/or active breastfeeding
* Glaucoma disease, epilepsy
* In addition for MRI: metal implants, electric devices, intolerance of contrast media, claustrophobia, renal or hepatic dysfunction (GFR \< 30 ml/min)
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Charite University, Berlin, Germany

OTHER

Sponsor Role lead

Responsible Party

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Kristin Kraeker

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anja Mähler, PhD

Role: PRINCIPAL_INVESTIGATOR

Charite University, Berlin, Germany

Locations

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Experimental and Clinical Research Center

Berlin, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Kristin Kräker, PhD

Role: CONTACT

+49 30 450540 328

Facility Contacts

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Anja Mähler, PhD

Role: primary

+49 30 450540 323

Kristin Kräker, PhD

Role: backup

+49 30 450540 328

Other Identifiers

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CARPE

Identifier Type: -

Identifier Source: org_study_id

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