The Clinical and Prognostic Features of PRES

NCT ID: NCT05143710

Last Updated: 2022-03-02

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 354 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-10-01
• Study Completion Date: 2022-01-31

Brief Summary

The purpose of this study is to determine the features of clinical imaging, disease severity and pregnancy outcomes in posterior reversible encephalopathy syndrome with preeclampsia or eclampsia.

Detailed Description

The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES with preeclampsia or eclampsia to analyze features of clinical imaging, disease severity and pregnancy outcomes during 2012 to 2021.Then, the investigators grouped all the patients into early onset group and late onset PE group according to gestational weeks to analyze differences of clinical imaging. Finally, the investigators grouped all the patients into good pregnancy outcomes group and poor pregnancy outcomes group according to diagnostic criteria, including the incidence of stillbirth and premature birth, to analyze differences of clinical imaging .

Conditions

Posterior Reversible Encephalopathy Syndrome; Pregnancy Outcomes; Preeclampsia; Eclampsia

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: RETROSPECTIVE

Study Groups

PRES in PE or E

patients diagnosed with PRES in PE or E

PRES in PE or E

Intervention Type: DIAGNOSTIC_TEST

patients diagnosed with posterior reversible encephalopathy syndrome with preeclampsia or eclampsia

Interventions

PRES in PE or E

patients diagnosed with posterior reversible encephalopathy syndrome with preeclampsia or eclampsia

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

1. patients were diagnosed of PRES with PE or E

2. all patients provided written informed consent

Exclusion Criteria

1. patients combined with other neurological disorders

2. patients combined with mental illness

• Minimum Eligible Age: 16 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Dunjin Chen

OTHER

Sponsor Role: lead

Responsible Party

Dunjin Chen

Director of obstetrics

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University

Guangzhou, , China

Countries

China

Other Identifiers

2020M682675

Identifier Type: -

Identifier Source: org_study_id