Serpin C and Soluble Fms-like Tyrosine Kinase-1 Levels in Normotensive Pregnant Women May Predict the Development of Preeclampsia

NCT ID: NCT06214702

Last Updated: 2024-01-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-07

Study Completion Date

2023-11-15

Brief Summary

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Evaluation of the predictability of estimated levels of Serpin C, sFlt-1 and placental growth factor (PLGF) in blood samples obtained during the 1st trimester from normotensive pregnant women for identification of women liable to develop PE during the course of pregnancy.

Detailed Description

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Conditions

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Pre-Eclampsia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Study group

Patients with diastolic blood pressure (DBP) after the 20th GW up ≥140 or 90 mmHg without proteinuria.

ELISA

Intervention Type DIAGNOSTIC_TEST

ELISA estimation of PLGF, sFlt-1 and Serpin C

Control Group

Patients were normotensive at the 20th GW.

ELISA

Intervention Type DIAGNOSTIC_TEST

ELISA estimation of PLGF, sFlt-1 and Serpin C

Interventions

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ELISA

ELISA estimation of PLGF, sFlt-1 and Serpin C

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Normotensive pregnant women had singleton fetus presenting during the 1st trimester

Exclusion Criteria

* Age
* Sex
* Hypertension
Minimum Eligible Age

25 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Benha University

OTHER

Sponsor Role lead

Responsible Party

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Omar K. Naser

lecturer of obstetrics and gynecology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Banha University

Banhā, El- Qalyobia, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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RC 7.1.2024

Identifier Type: -

Identifier Source: org_study_id

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