Plasma Brain Natriuretic Peptide Levels in Pregnancy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-08-31

Study Completion Date

2008-06-30

Brief Summary

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To evaluate the maternal blood concentrations of brain natriuretic peptide (BNP) during the second and third trimesters of a normal pregnancy. We will attempt to define a normal range for pregnancy and any outliers that may serve as markers for abnormal cardiovascular physiology.

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Detailed Description

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The brain natriuretic peptide (BNP) is a useful marker for volume overload, increased filling pressures and stretching of the myocardium. The current literature contains limited and unreliable information regarding normal BNP values in pregnancy. After baseline echocardiogram to detect individuals with asymptomatic structural defects, the participants will submit to 3 blood draws during the second and third trimester and at delivery to determine normal pregnancy values.

Conditions

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Cardiomyopathy Pregnancy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Healthy pregnant women, 18-40

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* women age 18 to 40
* second trimester of pregnancy

Exclusion Criteria

* known cardiac or valvular disease,
* atrial fibrillation or other arrhythmia,
* pulmonary hypertension,
* chronic hypertension,
* hypertensive disorders of pregnancy,
* morbid obesity (BMI \> 40 kg/meter squared)
* history of sleep apnea
* multiple gestation
* known renal dysfunction
* medications known to affect cardiac function
* current or past abnormal echocardiogram

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes