Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
100 participants
OBSERVATIONAL
2024-08-31
2026-07-01
Brief Summary
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Detailed Description
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In the WHO 2021 classification, there are three primary categories of adult-type diffuse gliomas: isocitrate dehydrogenase (IDH)-mutant, 1p/19q codeleted oligodendroglioma; IDH-mutant, non-codeleted astrocytoma; and IDH-wildtype glioblastoma. Diffuse low-grade glioma is classified as WHO grade 1 and 2 astrocytoma with IDH mutation or oligodendroglioma with IDH mutation and 1p/19q codeletion.
The presence of the IDH1 mutation has become a defining factor for adult diffuse low-grade glioma. Roughly 70% of grade 2-3 gliomas harbor mutations in either IDH1 or its mitochondrial counterpart IDH2.
Although lower-grade gliomas may present in various ways, the most common manifestation is seizures, and the development of seizures during the course of the disease may herald tumor progression. Among grade II tumors, the incidence of epilepsy is higher with IDH mutation. Anaplastic gliomas are somewhat less likely to manifest with seizures (57%) and are more likely than grade II gliomas to produce mental status, vision, and motor deficits.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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SURGICAL EXCISION
surgical excision of low grade glioma
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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M.Hossam Mohammad
principal investigator
Principal Investigators
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Ahmed El Gheriani, professor
Role: STUDY_CHAIR
professor
Central Contacts
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References
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Davis ME. Epidemiology and Overview of Gliomas. Semin Oncol Nurs. 2018 Dec;34(5):420-429. doi: 10.1016/j.soncn.2018.10.001. Epub 2018 Nov 2.
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021 Aug 2;23(8):1231-1251. doi: 10.1093/neuonc/noab106.
Mazzucchi E, La Rocca G, Ius T, Sabatino G, Della Pepa GM. Multimodality Imaging Techniques to Assist Surgery in Low-Grade Gliomas. World Neurosurg. 2020 Jan;133:423-425. doi: 10.1016/j.wneu.2019.10.120. No abstract available.
Other Identifiers
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Surgery of low grade glioma
Identifier Type: -
Identifier Source: org_study_id
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