Location-Molecular Integrated Outcomes in 450 Cerebellar Glioma Microsurgical Cases

NCT ID: NCT07342699

Last Updated: 2026-01-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 450 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-01-01
• Study Completion Date: 2024-06-01

Brief Summary

The goal of this observational study is to learn if refined anatomical location-combined with molecular biomarkers-can predict surgical success and long-term survival in 450 adults and children with cerebellar gliomas who underwent microsurgical resection at a single center between 2014 and 2024. The main questions it aims to answer are:

1. Does tumor location (cerebellar hemisphere, vermis, fourth ventricle, or pontocerebellar-angle region) independently influence extent of resection and overall survival after adjustment for WHO grade and molecular profile?

2. Among IDH-wild-type low-grade gliomas, does gross-total resection plus early adjuvant radiotherapy improve 5-year overall and progression-free survival compared with lesser resection or radiotherapy omission?

Researchers compared four anatomical subgroups and multiple molecular subtypes (IDH, 1p/19q, MGMT, TERT, BRAF V600E) to quantify location-specific resection rates, complication rates, and survival outcomes. Participants underwent standardized pre-operative imaging, microsurgical resection with intra-operative monitoring when indicated, post-operative MRI within 48 h to quantify residual tumor, and longitudinal clinical and radiographic follow-up every 3-12 months for up to 10 years.

Conditions

Gliomas

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: RETROSPECTIVE

Study Groups

Cerebellar hemisphere

Tumors arise from Cerebellar hemisphere

No interventions assigned to this group

Vermis

Tumors arise from Cerebellar Vermis

No interventions assigned to this group

Fourth ventricle

Tumors arise from Fourth ventricle

No interventions assigned to this group

Pontocerebellar-angle (PCA) region

tumors from Pontocerebellar-angle (PCA) region

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Pathologically proven cerebellar glioma (hemisphere, vermis, fourth ventricle, or pontocerebellar-angle region) per 2021 WHO CNS classification
• First microsurgical resection performed at our center between January 2014 and January 2024
• Age ≥ 3 years at surgery
• Pre-operative Karnofsky Performance Status (KPS) recorded
• Availability of post-operative contrast MRI for resection-extent calculation
• Minimum required molecular data: IDH1/2 status (immunohistochemistry ± sequencing)
• Continuous follow-up ≥ 6 months after surgery (out-patient visits or telephone confirmation)

Exclusion Criteria

• Brain-stem glioma with secondary cerebellar invasion
• Recurrent or metastatic glioma
• Previous cranial radiation or glioma surgery at another institution
• Palliative resection (< 20 % of tumor volume removed)
• Missing post-operative MRI or insufficient tissue for mandatory IDH testing
• Follow-up < 6 months or lost to follow-up before 6-month landmark

• Minimum Eligible Age: 3 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

West China Hospital

OTHER

Sponsor Role: lead

Responsible Party

Zhigang Lan

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

West China Hospital of Sichuan University

Chengdu, Sichuan, China

Countries

China

Other Identifiers

WestChinaH-HX-2025-09

Identifier Type: -

Identifier Source: org_study_id